CERAD（阿尔茨海默病研究联盟）神经心理学评估工具包：35 年的历程与展望。
CERAD (Consortium to Establish a Registry for Alzheimer's Disease) Neuropsychology Assessment Battery: 35 Years and Counting.
机构信息
Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA.
Global Alzheimer's Platform Foundation, Washington, DC, USA.
出版信息
J Alzheimers Dis. 2023;93(1):1-27. doi: 10.3233/JAD-230026.
BACKGROUND
In 1986, the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) was mandated to develop a brief neuropsychological assessment battery (CERAD-NAB) for AD, for uniform neuropsychological assessment, and information aggregation. Initially used across the National Institutes of Aging-funded Alzheimer's Disease Research Centers, it has become widely adopted wherever information is desired on cognitive status and change therein, particularly in older populations.
OBJECTIVE
Our purpose is to provide information on the multiple uses of the CERAD-NAB since its inception, and possible further developments.
METHODS
Since searching on "CERAD neuropsychological assessment battery" or similar terms missed important information, "CERAD" alone was entered into PubMed and SCOPUS, and CERAD-NAB use identified from the resulting studies. Use was sorted into major categories, e.g., psychometric information, norms, dementia/differential dementia diagnosis, epidemiology, intervention evaluation, genetics, etc., also translations, country of use, and alternative data gathering approaches.
RESULTS
CERAD-NAB is available in ∼20 languages. In addition to its initial purpose assessing AD severity, CERAD-NAB can identify mild cognitive impairment, facilitate differential dementia diagnosis, determine cognitive effects of naturally occurring and experimental interventions (e.g., air pollution, selenium in soil, exercise), has helped to clarify cognition/brain physiology-neuroanatomy, and assess cognitive status in dementia-risk conditions. Surveys of primary and tertiary care patients, and of population-based samples in multiple countries have provided information on prevalent and incident dementia, and cross-sectional and longitudinal norms for ages 35-100 years.
CONCLUSION
CERAD-NAB has fulfilled its original mandate, while its uses have expanded, keeping up with advances in the area of dementia.
背景
1986 年，阿尔茨海默病研究联合会（CERAD）受命开发一种简短的神经心理学评估工具包（CERAD-NAB），用于统一的神经心理学评估和信息汇总。该工具最初在国家老龄化研究所资助的阿尔茨海默病研究中心使用，现已广泛应用于需要了解认知状态和变化的地方，尤其是在老年人群中。
目的
我们的目的是提供自成立以来 CERAD-NAB 的多种用途的信息，以及可能的进一步发展。
方法
由于搜索“CERAD 神经心理学评估工具包”或类似术语会错过重要信息，因此仅在 PubMed 和 SCOPUS 中输入“CERAD”，并从相关研究中确定 CERAD-NAB 的使用情况。用途分为主要类别，例如心理计量学信息、常模、痴呆症/鉴别痴呆症诊断、流行病学、干预评估、遗传学等，也包括翻译、使用国家和替代数据收集方法。
结果
CERAD-NAB 有大约 20 种语言的版本。除了最初评估 AD 严重程度的目的外，CERAD-NAB 还可以识别轻度认知障碍，有助于鉴别痴呆症诊断，确定自然发生和实验干预的认知影响（例如，空气污染、土壤中的硒、运动），有助于阐明认知/大脑生理学-神经解剖学，并评估痴呆症风险条件下的认知状态。对初级和三级保健患者以及多个国家的人群进行的调查提供了有关普遍和新发痴呆症的信息，以及 35-100 岁年龄的横断面和纵向常模。
结论
CERAD-NAB 已经完成了其最初的任务，同时其用途也在不断扩大，跟上了痴呆症领域的发展。
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