• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

急性重度溃疡性结肠炎的当代医学管理

Contemporary Medical Management of Acute Severe Ulcerative Colitis.

机构信息

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

出版信息

Inflamm Bowel Dis. 2019 Jan 1;25(1):56-66. doi: 10.1093/ibd/izy208.

DOI:10.1093/ibd/izy208
PMID:29889235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6290785/
Abstract

Acute severe ulcerative colitis is a medical emergency that requires prompt recognition, evaluation, and intervention. Patients require hospital admission with laboratory, radiographic, and endoscopic evaluation with initiation of corticosteroid treatment. Despite early intervention, many patients require salvage medical therapy, with some progressing to colectomy. Here we review important concepts and recent advances in the evaluation and medical management of adult and pediatric patients with acute severe ulcerative colitis.

摘要

急性重度溃疡性结肠炎是一种医学急症，需要及时识别、评估和干预。患者需要住院，进行实验室、影像学和内镜评估，并开始皮质类固醇治疗。尽管早期干预，许多患者仍需要挽救性药物治疗，部分患者进展为结肠切除术。本文复习了成人和儿童急性重度溃疡性结肠炎患者的评估和药物治疗的重要概念和最新进展。

相似文献

1
Contemporary Medical Management of Acute Severe Ulcerative Colitis.急性重度溃疡性结肠炎的当代医学管理
Inflamm Bowel Dis. 2019 Jan 1;25(1):56-66. doi: 10.1093/ibd/izy208.
2
Predicting response after infliximab salvage in acute severe ulcerative colitis.预测英夫利昔单抗挽救治疗急性重度溃疡性结肠炎的应答。
J Gastroenterol Hepatol. 2018 Jul;33(7):1347-1352. doi: 10.1111/jgh.14072. Epub 2018 Feb 27.
3
Inpatient Management of Acute Severe Ulcerative Colitis.急性重度溃疡性结肠炎的住院治疗。
J Hosp Med. 2019 Dec 1;14(12):766-773. doi: 10.12788/jhm.3207. Epub 2019 May 12.
4
Tofacitinib Salvage Therapy for Children Hospitalized for Corticosteroid- and Biologic-Refractory Ulcerative Colitis.托法替布挽救治疗用于因皮质类固醇和生物制剂难治性溃疡性结肠炎住院的儿童。
J Pediatr Gastroenterol Nutr. 2022 Dec 1;75(6):724-730. doi: 10.1097/MPG.0000000000003616. Epub 2022 Sep 19.
5
Association between the ulcerative colitis endoscopic index of severity (UCEIS) and outcomes in acute severe ulcerative colitis.溃疡性结肠炎内镜严重程度指数（UCEIS）与急性重症溃疡性结肠炎预后的相关性
J Crohns Colitis. 2015 May;9(5):376-81. doi: 10.1093/ecco-jcc/jjv047. Epub 2015 Mar 13.
6
Role of surgery in severe ulcerative colitis in the era of medical rescue therapy.手术在医学救援治疗时代中对于重度溃疡性结肠炎的作用。
World J Gastroenterol. 2012 Aug 7;18(29):3833-8. doi: 10.3748/wjg.v18.i29.3833.
7
Short- and long-term efficacy of adalimumab salvage therapy after failure of calcineurin inhibitors in steroid-refractory ulcerative colitis.钙调神经磷酸酶抑制剂治疗失败后，阿达木单抗挽救疗法在激素难治性溃疡性结肠炎中的短期和长期疗效
Scand J Gastroenterol. 2018 Oct-Nov;53(10-11):1236-1244. doi: 10.1080/00365521.2018.1511825. Epub 2018 Oct 24.
8
Systematic Review and Meta-analysis: Optimal Salvage Therapy in Acute Severe Ulcerative Colitis.系统评价和荟萃分析：急性重度溃疡性结肠炎的最佳挽救治疗。
Inflamm Bowel Dis. 2019 Jun 18;25(7):1169-1186. doi: 10.1093/ibd/izy383.
9
Management of acute severe ulcerative colitis in children.儿童急性重症溃疡性结肠炎的管理
Semin Pediatr Surg. 2017 Dec;26(6):367-372. doi: 10.1053/j.sempedsurg.2017.10.006. Epub 2017 Oct 5.
10
Initial medical management of severe acute ulcerative colitis.重度急性溃疡性结肠炎的初始药物治疗
Acta Gastroenterol Belg. 2000 Jul-Sep;63(3):275-8.

引用本文的文献

1
Intensified Upadacitinib Dosing for Adolescent Patients with Acute Severe Ulcerative Colitis.用于青少年急性重度溃疡性结肠炎患者的乌帕替尼强化给药方案。
Children (Basel). 2025 Mar 22;12(4):401. doi: 10.3390/children12040401.
2
Management of ulcerative colitis in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease updated in 2023.台湾溃疡性结肠炎的管理：2023年更新的台湾炎症性肠病学会共识指南
Intest Res. 2024 Jul;22(3):213-249. doi: 10.5217/ir.2023.00050. Epub 2024 Jul 29.
3
Navigating the Intersection: Sarcopenia and Sarcopenic Obesity in Inflammatory Bowel Disease.探索交叉点：炎症性肠病中的肌肉减少症和肌肉减少性肥胖症
Biomedicines. 2024 May 30;12(6):1218. doi: 10.3390/biomedicines12061218.
4
Rescue Therapy for Acute Severe Ulcerative Colitis: A Case Report.急性重症溃疡性结肠炎的挽救治疗：一例报告
Gastroenterol Hepatol (N Y). 2023 Mar;19(3):176-179.
5
Computer-Aided Screening and Revealing Action Mechanism of Food-Derived Tripeptides Intervention in Acute Colitis.计算机辅助筛选与揭示食源性三肽干预急性结肠炎的作用机制。
Int J Mol Sci. 2022 Nov 3;23(21):13471. doi: 10.3390/ijms232113471.
6
Fecal Calprotectin Is a Predictor of Need for Rescue Therapy in Hospitalized Severe Colitis.粪便钙卫蛋白可预测住院重度结肠炎患者是否需要挽救性治疗。
Inflamm Bowel Dis. 2022 Dec 1;28(12):1833-1837. doi: 10.1093/ibd/izac011.
7
Sarcopenia assessed by computed tomography is associated with colectomy in patients with acute severe ulcerative colitis.通过计算机断层扫描评估的肌肉减少症与急性重症溃疡性结肠炎患者的结肠切除术有关。
Eur J Clin Nutr. 2022 Mar;76(3):410-418. doi: 10.1038/s41430-021-00953-y. Epub 2021 Jun 15.
8
Cytomegalovirus and Inflammatory Bowel Diseases (IBD) with a Special Focus on the Link with Ulcerative Colitis (UC).巨细胞病毒与炎症性肠病（IBD），特别关注与溃疡性结肠炎（UC）的关联。
Microorganisms. 2020 Jul 20;8(7):1078. doi: 10.3390/microorganisms8071078.
9
Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.糖皮质激素通过上调肠上皮细胞中的mTOR信号促进急性实验性结肠炎和癌症的发生。
Cancers (Basel). 2020 Apr 11;12(4):945. doi: 10.3390/cancers12040945.
10
Has infliximab influenced the course and prognosis of acute severe ulcerative colitis?英夫利昔单抗对急性重症溃疡性结肠炎的病程及预后有影响吗？
Biologics. 2019 Apr 9;13:23-31. doi: 10.2147/BTT.S179006. eCollection 2019.

本文引用的文献

1
Outcomes of a National Cohort of Children with Acute Severe Ulcerative Colitis.一组全国性急性重症溃疡性结肠炎患儿的研究结果。
Front Pediatr. 2018 Mar 8;6:48. doi: 10.3389/fped.2018.00048. eCollection 2018.
2
Hyperbaric oxygen therapy is well tolerated and effective for ulcerative colitis patients hospitalized for moderate-severe flares: a phase 2A pilot multi-center, randomized, double-blind, sham-controlled trial.高压氧疗法在中重度溃疡性结肠炎住院患者中耐受性良好且有效：一项 2A 期多中心、随机、双盲、假对照试验。
Am J Gastroenterol. 2018 Oct;113(10):1516-1523. doi: 10.1038/s41395-018-0005-z. Epub 2018 Feb 16.
3
Cytomegalovirus Infection in Pediatric Severe Ulcerative Colitis-A Multicenter Study from the Pediatric Inflammatory Bowel Disease Porto Group of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition.儿童重症溃疡性结肠炎中的巨细胞病毒感染——来自于儿童炎症性肠病波尔图小组的一个多中心研究，该小组隶属于欧洲儿童胃肠病学、肝病学和营养学学会。
Pediatr Infect Dis J. 2018 Mar;37(3):197-201. doi: 10.1097/INF.0000000000001724.
4
The efficacy and safety of the biosimilar product (Inflectra) compared to the reference drug (Remicade) in rescue therapy in adult patients with ulcerative colitis.生物类似药产品（英夫利昔单抗生物类似药）与参比药物（类克）相比，用于成年溃疡性结肠炎患者抢救治疗的疗效和安全性。
Prz Gastroenterol. 2017;12(3):169-174. doi: 10.5114/pg.2017.70468. Epub 2017 Sep 30.
5
Exploration of Predictive Biomarkers of Early Infliximab Response in Acute Severe Colitis: A Prospective Pilot Study.急性重度结肠炎中早期英夫利昔单抗反应的预测性生物标志物的探索：一项前瞻性初步研究。
J Crohns Colitis. 2018 Feb 28;12(3):289-297. doi: 10.1093/ecco-jcc/jjx146.
6
Factors associated with early outcomes following standardised therapy in children with ulcerative colitis (PROTECT): a multicentre inception cohort study.与溃疡性结肠炎患儿标准化治疗后早期结局相关的因素（PROTECT）：一项多中心发病队列研究。
Lancet Gastroenterol Hepatol. 2017 Dec;2(12):855-868. doi: 10.1016/S2468-1253(17)30252-2. Epub 2017 Sep 20.
7
Colonic cytomegalovirus detection by mucosal PCR and antiviral therapy in ulcerative colitis.通过黏膜聚合酶链反应检测溃疡性结肠炎中的结肠巨细胞病毒及抗病毒治疗
PLoS One. 2017 Sep 8;12(9):e0183951. doi: 10.1371/journal.pone.0183951. eCollection 2017.
8
Increased Rate of Venous Thromboembolism in Hospitalized Inflammatory Bowel Disease Patients with Clostridium Difficile Infection.住院炎症性肠病合并艰难梭菌感染患者的静脉血栓栓塞发生率增加。
Inflamm Bowel Dis. 2017 Oct;23(10):1847-1852. doi: 10.1097/MIB.0000000000001218.
9
Therapeutic Drug Monitoring During Induction of Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease: Defining a Therapeutic Drug Window.在炎症性肠病中诱导抗肿瘤坏死因子治疗期间的治疗药物监测：定义治疗药物窗口。
Inflamm Bowel Dis. 2017 Sep;23(9):1510-1515. doi: 10.1097/MIB.0000000000001231.
10
Long-Term Efficacy and Safety of Cyclosporine in a Cohort of Steroid-Refractory Acute Severe Ulcerative Colitis Patients from the ENEIDA Registry (1989-2013): A Nationwide Multicenter Study.环孢素在ENEIDA注册研究（1989 - 2013年）中一组激素难治性急性重症溃疡性结肠炎患者中的长期疗效及安全性：一项全国性多中心研究
Am J Gastroenterol. 2017 Nov;112(11):1709-1718. doi: 10.1038/ajg.2017.180. Epub 2017 Jul 4.