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本文引用的文献

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High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human.人类转录调控区域和核苷酸的高分辨率全基因组功能剖析。
Nat Commun. 2018 Dec 19;9(1):5380. doi: 10.1038/s41467-018-07746-1.
2
Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells.人类胚胎干细胞中增强子谱的功能剖析。
Cell Stem Cell. 2018 Aug 2;23(2):276-288.e8. doi: 10.1016/j.stem.2018.06.014. Epub 2018 Jul 19.
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Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities.转录起始位点分析揭示了 D. melanogaster 中的广泛分歧转录和核心启动子编码增强子活性。
Nucleic Acids Res. 2018 Jun 20;46(11):5455-5469. doi: 10.1093/nar/gky244.
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Enhancer transcription: what, where, when, and why?增强子转录：是什么、在哪里、何时以及为何？
Genes Dev. 2018 Jan 1;32(1):1-3. doi: 10.1101/gad.311605.118.
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The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription.增强子或启动子活性的程度反映在 eRNA 转录的水平和方向性上。
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Widespread transcriptional pausing and elongation control at enhancers.广泛的转录暂停和延伸控制增强子。
Genes Dev. 2018 Jan 1;32(1):26-41. doi: 10.1101/gad.309351.117. Epub 2018 Jan 29.
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Resolving systematic errors in widely used enhancer activity assays in human cells.解决人类细胞中广泛使用的增强子活性测定中的系统误差。
Nat Methods. 2018 Feb;15(2):141-149. doi: 10.1038/nmeth.4534. Epub 2017 Dec 11.
8
Functional assessment of human enhancer activities using whole-genome STARR-sequencing.使用全基因组 STARR-seq 技术对人类增强子活性进行功能评估。
Genome Biol. 2017 Nov 20;18(1):219. doi: 10.1186/s13059-017-1345-5.
9
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.原代人类细胞中的增强子连接组可识别疾病相关DNA元件的靶基因。
Nat Genet. 2017 Nov;49(11):1602-1612. doi: 10.1038/ng.3963. Epub 2017 Sep 25.
10
Recent advances in high-throughput approaches to dissect enhancer function.剖析增强子功能的高通量方法的最新进展。
F1000Res. 2017 Jun 19;6:939. doi: 10.12688/f1000research.11581.1. eCollection 2017.

具有增强子功能的启动子的转录调控。

Transcriptional regulation by promoters with enhancer function.

作者信息

Dao Lan T M, Spicuglia Salvatore

机构信息

a Vinmec Research Institute of Stem cell and Gene technology (VRISG) , Hanoi , Vietnam.

b Aix-Marseille University, INSERM, TAGC, UMR , Marseille , France.

出版信息

Transcription. 2018;9(5):307-314. doi: 10.1080/21541264.2018.1486150. Epub 2018 Jun 25.

DOI:10.1080/21541264.2018.1486150
PMID:29889606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6150634/
Abstract

UNLABELLED

Promoters with enhancer activity have been described recently. In this point of view, we will discuss current findings highlighting the commonality of this type of regulatory elements, their genetic and epigenetic characteristics, their potential biological roles in the regulation of gene expression and the underlining molecular mechanisms.

ABBREVIATIONS

TSS: transcription start site; IFN: interferon; STARR-seq: Self-Transcribing Active Regulatory Region sequencing; MPRA: Massively Parallel Reporter Assay; ChIP: chromatin immunoprecipitation; CRISPR: Clustered Regularly Interspaced Short Palindromic Repeats; lncRNA: long non-coding RNA.

摘要

未标记

最近已经描述了具有增强子活性的启动子。从这个角度来看，我们将讨论当前的研究结果，突出这类调控元件的共性、它们的遗传和表观遗传特征、它们在基因表达调控中的潜在生物学作用以及潜在的分子机制。

缩写

TSS：转录起始位点；IFN：干扰素；STARR-seq：自转录活性调控区域测序；MPRA：大规模平行报告基因检测；ChIP：染色质免疫沉淀；CRISPR：成簇规律间隔短回文重复序列；lncRNA：长链非编码RNA。