Koopmann Mario, Rudack Claudia, Weiss Daniel, Stenner Markus
HNO-Praxis Dr. med. Mario Koopmann.
Universitätsklinikum Münster, Abteilung für Hals-Nasen-Ohrenheilkunde, Kopf-Halschirurgie.
Laryngorhinootologie. 2018 Jun;97(6):379-391. doi: 10.1055/a-0592-7965. Epub 2018 Jun 11.
Squamous cell carcinoma of the nasal vestibule is a rare entity. In consequence disagreement in etiology, staging system and therapy of primary tumor with or without adjuvant treatment of regional lymph nodes are apparent.
Pubmed-Recherche of relevant literature concerning: lymphatic drainage, metastases, incidence, risk factors (leather, nickel, nicotine, human papillomavirus, Staging system (UICC, AJCC, Wang's system), therapy of the primary tumor, regional lymph nodes and immunohistochemistry.
Fifty-five studies were found and analyzed. Results are inconsistent.
The Wang-classification is recommended. Radiation and surgery are the treatment of choice for small lesions. Larger lesions (T3-Wang) should be treated with a combined approach. In cT1-cT2cN0-situation after accurate diagnostic, an elective therapy of regional lymph nodes is not necessary.
鼻前庭鳞状细胞癌是一种罕见的疾病。因此，在原发性肿瘤的病因、分期系统以及是否进行区域淋巴结辅助治疗的治疗方法上存在明显分歧。
在PubMed上检索有关以下方面的相关文献：淋巴引流、转移、发病率、危险因素（皮革、镍、尼古丁、人乳头瘤病毒）、分期系统（国际抗癌联盟（UICC）、美国癌症联合委员会（AJCC）、王氏系统）、原发性肿瘤的治疗、区域淋巴结以及免疫组织化学。
共检索并分析了55项研究。结果不一致。
推荐王氏分类法。对于小病灶，放疗和手术是首选治疗方法。较大的病灶（T3 - 王氏分类）应采用联合治疗方法。在准确诊断后的cT1 - cT2cN0情况下，无需对区域淋巴结进行选择性治疗。
