Vascular Neurology Program, Mercy Health Hauenstein Neurosciences, 220 Cherry Street SE Room H 3037, Grand Rapids, MI 49503, United States.
Vascular Neurology Program, Mercy Health Hauenstein Neurosciences, 220 Cherry Street SE Room H 3037, Grand Rapids, MI 49503, United States; Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, MI United States.
Trends Cardiovasc Med. 2019 Jan;29(1):12-18. doi: 10.1016/j.tcm.2018.05.011. Epub 2018 Jun 2.
The relationship of blood pressure to cognition in the elderly is a poorly understood topic. Many questions exist such as does treatment of hypertension prevent cognitive decline, the optimal timing of intervention and selecting the appropriate agent. In this review we will explore recent epidemiologic data and clinical trials addressing hypertension and cognition, review pathophysiology of chronic hypertension and effects of brain function, discuss the timing of intervention and finally review opportunities for future research.
老年人的血压与认知能力的关系是一个尚未被充分理解的课题。存在许多问题，例如高血压的治疗是否可以预防认知能力下降、干预的最佳时机以及选择合适的药物。在这篇综述中，我们将探讨最近的流行病学数据和临床试验，以了解高血压和认知能力的关系，回顾慢性高血压的病理生理学及其对大脑功能的影响，讨论干预的时机，最后综述未来研究的机会。
