Sowndhararajan Kandhasamy, Deepa Ponnuvel, Kim Minju, Park Se Jin, Kim Songmun
School of Natural Resources and Environmental Science, Kangwon National University, Chuncheon 24341, Gangwon-do, Korea.
Brain Sci. 2018 Jun 11;8(6):104. doi: 10.3390/brainsci8060104.
Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the gradual loss of neurons. The development of effective neuroprotective agents to prevent and control neurodegenerative diseases is specifically important. Recently, there has been an increasing interest in selecting flavonoid compounds as potential neuroprotective agents, owing to their high effectiveness with low side effects. Baicalin is one of the important flavonoid compounds, which is mainly isolated from the root of Georgi (an important Chinese medicinal herb). In recent years, a number of studies have shown that baicalin has a potent neuroprotective effect in various in vitro and in vivo models of neuronal injury. In particular, baicalin effectively prevents neurodegenerative diseases through various pharmacological mechanisms, including antioxidative stress, anti-excitotoxicity, anti-apoptotic, anti-inflammatory, stimulating neurogenesis, promoting the expression of neuronal protective factors, etc. This review mainly focuses on the neuroprotective and cognitive enhancement effects of baicalin. The aim of the present review is to compile all information in relation to the neuroprotective and cognitive enhancement effects of baicalin and its molecular mechanisms of action in various in vitro and in vivo experimental models.
神经退行性疾病是一组异质性疾病，其特征是神经元逐渐丧失。开发有效的神经保护剂以预防和控制神经退行性疾病尤为重要。最近，由于黄酮类化合物高效且副作用低，人们对选择其作为潜在神经保护剂的兴趣日益增加。黄芩苷是重要的黄酮类化合物之一，主要从黄芩（一种重要的中药材）的根部提取。近年来，多项研究表明，黄芩苷在各种体外和体内神经元损伤模型中具有强大的神经保护作用。特别是，黄芩苷通过多种药理机制有效预防神经退行性疾病，包括抗氧化应激、抗兴奋毒性、抗凋亡、抗炎、刺激神经发生、促进神经元保护因子的表达等。本综述主要关注黄芩苷的神经保护和认知增强作用。本综述的目的是汇总所有与黄芩苷的神经保护和认知增强作用及其在各种体外和体内实验模型中的作用分子机制相关的信息。
