Zhang Yuqun, Yang Yuan, Wang Ze, Bian Rongrong, Jiang Wenhao, Yin Yingying, Yue Yingying, Hou Zhenghua, Yuan Yonggui
Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China.
Institute of Psychosomatics, School of Medicine, Southeast University, Nanjing, China.
Front Psychiatry. 2018 May 28;9:225. doi: 10.3389/fpsyt.2018.00225. eCollection 2018.
Asthma is a chronic disease appeared to be associated with depression. But the underpinnings of depression in asthma remain unknown. In order to understand the neural mechanisms of depression in asthma, we used cerebral blood flow (CBF) to probe the difference between depressed asthmatic (DA) and non-depressed asthmatic (NDA) patients. Eighteen DA patients, 24 NDA patients and 57 healthy controls (HC) received pulsed arterial spin labeling (pASL) scan for measuring CBF, resting-state functional magnetic resonance imaging (rs-fMRI) scan, severity of depression and asthma control assessment, respectively. Compared to NDA, DA patients showed increased regional CBF (rCBF) in the right cerebellum posterior lobe. Compared to HC, DA, and NDA patients all showed significantly decreased rCBF in the right cerebellum posterior lobe. We showed the first evidence of altered rCBF in the right cerebellum posterior lobe in asthma using pASL, which appeared to be involved in the neuropathology in asthma. An investigation of therapeutic mechanism in asthmatic patients: based on the results of Group Cognitive Behavioral Therapy (Registration number: ChiCTR-COC-15007442) (http://www.chictr.org.cn/usercenter.aspx).
哮喘是一种似乎与抑郁症相关的慢性疾病。但哮喘中抑郁症的潜在机制尚不清楚。为了了解哮喘中抑郁症的神经机制，我们使用脑血流量（CBF）来探究抑郁哮喘（DA）患者和非抑郁哮喘（NDA）患者之间的差异。18名DA患者、24名NDA患者和57名健康对照者（HC）分别接受了脉冲动脉自旋标记（pASL）扫描以测量CBF、静息态功能磁共振成像（rs-fMRI）扫描、抑郁症严重程度和哮喘控制评估。与NDA相比，DA患者右侧小脑后叶的局部脑血流量（rCBF）增加。与HC相比，DA和NDA患者右侧小脑后叶的rCBF均显著降低。我们首次使用pASL证明了哮喘患者右侧小脑后叶rCBF的改变，这似乎与哮喘的神经病理学有关。哮喘患者治疗机制的研究：基于团体认知行为疗法的结果（注册号：ChiCTR-COC-15007442）（http://www.chictr.org.cn/usercenter.aspx）。
