Zhang Yuqun, Kong Youyong, Yang Yuan, Yin Yingyin, Hou Zhenghua, Xu Zhi, Yuan Yonggui
School of Nursing, Nanjing University of Chinese Medicine, Nanjing, China.
Department of Psychosomatic and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Front Neurol. 2021 Mar 12;12:615820. doi: 10.3389/fneur.2021.615820. eCollection 2021.
Group cognitive behavior therapy (GCBT) is a successful therapy for asthma. However, the neural biomarker of GCBT which could be used in clinic remains unclear. The temporal variability is a novel concept to characterize the dynamic functional connectivity (FC), which has many advantages as biomarker. Therefore, the aim of this study is to explore the potential difference of temporal variability between asthmatic patients and healthy controls, then determine the different patterns of temporal variability between pre- and post-treatment group and reveal the relationship between the variability and the symptoms improvement reduced by GCBT. At baseline, 40 asthmatic patients and 40 matched controls received resting-state functional magnetic resonance imaging (fMRI) scans and clinical assessments. After 8 weeks of GCBT treatment, 17 patients received fMRI scans, and assessments again. Temporal variability at baseline and post-treatment were calculated for further analysis. Compared with controls, asthmatic patients showed widespread decreases in temporal variability. Moreover, the variability in both right caudate and left putamen were positively correlated with asthma control level. After GCBT, asthma control level and depression of patients were improved. Meanwhile, compared with pre-GCBT, patients after treatment showed lower variability in left opercular of Rolandic, right parahippocampal gyrus and right lingual gyrus, as well as higher variability in left temporal pole. Variability in regions which were found abnormal at baseline did not exhibit significant differences between post-GCBT and controls. Asthma-specific changes of dynamic functional connectivity may serve as promising underpinnings of GCBT for asthma. http://www.chictr.org.cn/index.aspx, identifier: Chi-CTR-15007442.
团体认知行为疗法（GCBT）是一种治疗哮喘的成功疗法。然而，可用于临床的GCBT神经生物标志物仍不明确。时间变异性是表征动态功能连接（FC）的一个新概念，作为生物标志物有诸多优势。因此，本研究旨在探讨哮喘患者与健康对照之间时间变异性的潜在差异，确定治疗前和治疗后组之间时间变异性的不同模式，并揭示变异性与GCBT减轻的症状改善之间的关系。在基线时，40名哮喘患者和40名匹配的对照接受静息态功能磁共振成像（fMRI）扫描和临床评估。经过8周的GCBT治疗后，17名患者再次接受fMRI扫描和评估。计算基线和治疗后的时间变异性以进行进一步分析。与对照组相比，哮喘患者的时间变异性普遍降低。此外，右侧尾状核和左侧壳核的变异性与哮喘控制水平呈正相关。GCBT治疗后，患者的哮喘控制水平和抑郁症状得到改善。同时，与GCBT治疗前相比，治疗后患者在左侧中央前回岛盖、右侧海马旁回和右侧舌回的变异性较低，而在左侧颞极的变异性较高。基线时发现异常区域的变异性在GCBT治疗后与对照组之间未表现出显著差异。哮喘特异性的动态功能连接变化可能是GCBT治疗哮喘的有前景的基础。http://www.chictr.org.cn/index.aspx，标识符：Chi-CTR-15007442
