Donadon Matteo, Lleo Ana, Di Tommaso Luca, Soldani Cristiana, Franceschini Barbara, Roncalli Massimo, Torzilli Guido
Department of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center, Rozzano, Italy.
Department of Biomedical Science, Humanitas University, Rozzano, Italy.
Front Oncol. 2018 May 28;8:181. doi: 10.3389/fonc.2018.00181. eCollection 2018.
The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.
传统上,人们一直在原发性结直肠癌肿瘤或结直肠癌肝转移(CLM)的肿瘤因素中寻找CLM患者预后的决定因素。虽然基于这些临床病理因素开发了许多不同的评分系统,结果却不尽相同,但基因生物标志物的引入为治疗诊断带来了新视角。最近,其他重要因素,如与宿主免疫系统相关的因素,也被提出作为CLM患者预后的决定因素。在本研究中,我们回顾了CLM患者当前的预后因素,以及依赖于宿主免疫系统的新兴预后模式转变。