State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China.
Food Funct. 2018 Jun 20;9(6):3509-3522. doi: 10.1039/c8fo00100f.
Host gut microbiota dysbiosis occurs for multiple reasons and is often accompanied by chronic inflammation induced by a high-fat-high-sucrose (HFHS) diet and related metabolic disorders. Intervention with probiotics is a novel strategy for amelioration of metabolic syndrome, which is believed to regulate the gut microbiota composition to some extent. We investigated the relationship amongst bifidobacteria treatment, HFHS diet-induced metabolic disorders and the gut microbiota composition. Seven strains of bifidobacteria from four species were individually administered to rats fed a HFHS diet for 12 weeks. Various bifidobacteria strains showed various effects on the recovery of metabolic disorders and gut microbiota dysbiosis, and these effects seemed to be inter- or intra-species specific. Bifidobacterium longum, B. adolescentis and B. bifidum seemed to affect the blood glucose balance, whilst two strains of B. breve showed extremely different effects in this area. However, only one strain of B. longum and the B. adolescentis displayed significant regulation of blood lipid levels. The protective effects of bifidobacteria on the pancreas were strongly correlated with those on blood glucose. Furthermore, the influence of bifidobacteria on gut microbiota dysbiosis also showed a potential relationship with symptoms of metabolic disorders. Of these seven strains, B. adolescentis Z25 displayed an outstanding ability to alleviate metabolic syndrome, including glucose and lipid metabolism disorders, tissue damage and gut microbiota dysbiosis. This strain, coupled with other prebiotics and probiotics, could be used as a potential treatment approach for metabolic syndrome induced by a HFHS diet.
宿主肠道微生物群落失调有多种原因，常伴有高脂肪高糖（HFHS）饮食诱导的慢性炎症和相关代谢紊乱。益生菌干预是改善代谢综合征的一种新策略，它被认为在一定程度上可以调节肠道微生物群落组成。我们研究了双歧杆菌治疗、HFHS 饮食诱导的代谢紊乱与肠道微生物群落组成之间的关系。将来自四个种属的七种双歧杆菌菌株分别给予 HFHS 饮食喂养 12 周的大鼠。各种双歧杆菌菌株对代谢紊乱和肠道微生物群落失调的恢复有不同的影响，这些影响似乎在种属间或种内是特异性的。长双歧杆菌、青春双歧杆菌和两歧双歧杆菌似乎影响血糖平衡，而两株短双歧杆菌在这方面表现出极其不同的作用。然而，只有一株长双歧杆菌和青春双歧杆菌对血脂水平有显著的调节作用。双歧杆菌对胰腺的保护作用与血糖调节密切相关。此外，双歧杆菌对肠道微生物群落失调的影响也与代谢紊乱的症状表现出潜在的关系。在这七种菌株中，双歧杆菌 Z25 表现出缓解代谢综合征的卓越能力，包括葡萄糖和脂质代谢紊乱、组织损伤和肠道微生物群落失调。这种菌株与其他益生元和益生菌联合使用，可能成为 HFHS 饮食诱导的代谢综合征的一种潜在治疗方法。
