黄酮类化合物对与年龄相关的认知衰退和神经退行性变潜在的细胞和分子机制的影响。
Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration.
作者信息
Flanagan Emma, Müller Michael, Hornberger Michael, Vauzour David
机构信息
Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7UQ, UK.
出版信息
Curr Nutr Rep. 2018 Jun;7(2):49-57. doi: 10.1007/s13668-018-0226-1.
PURPOSE OF REVIEW
This review summarises the most recent evidence regarding the effects of dietary flavonoids on age-related cognitive decline and neurodegenerative diseases.
RECENT FINDINGS
Recent evidence indicates that plant-derived flavonoids may exert powerful actions on mammalian cognition and protect against the development of age-related cognitive decline and pathological neurodegeneration. The neuroprotective effects of flavonoids have been suggested to be due to interactions with the cellular and molecular architecture of brain regions responsible for memory. Mechanisms for the beneficial effects of flavonoids on age-related cognitive decline and dementia are discussed, including modulating signalling pathways critical in controlling synaptic plasticity, reducing neuroinflammation, promoting vascular effects capable of stimulating new nerve cell growth in the hippocampus, bidirectional interactions with gut microbiota and attenuating the extracellular accumulation of pathological proteins. These processes are known to be important in maintaining optimal neuronal function and preventing age-related cognitive decline and neurodegeneration.
综述目的
本综述总结了关于膳食类黄酮对与年龄相关的认知衰退和神经退行性疾病影响的最新证据。
最新发现
最新证据表明，植物来源的类黄酮可能对哺乳动物的认知产生强大作用，并预防与年龄相关的认知衰退和病理性神经退行性变的发展。类黄酮的神经保护作用被认为是由于与负责记忆的脑区的细胞和分子结构相互作用。讨论了类黄酮对与年龄相关的认知衰退和痴呆有益作用的机制，包括调节对控制突触可塑性至关重要的信号通路、减轻神经炎症、促进能够刺激海马体中新神经细胞生长的血管效应、与肠道微生物群的双向相互作用以及减少病理性蛋白质的细胞外积累。已知这些过程对于维持最佳神经元功能以及预防与年龄相关的认知衰退和神经退行性变很重要。
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