Hunt Thomas, Pontifex Matthew G, Vauzour David
Norwich Medical School, University of East Anglia, Norwich, UK.
FEBS Lett. 2024 Dec;598(24):2949-2962. doi: 10.1002/1873-3468.14988. Epub 2024 Jul 23.
(Poly)phenols are a group of naturally occurring phytochemicals present in high amounts in plant food and beverages with various structures and activities. The impact of (poly)phenols on brain function has gained significant attention due to the growing interest in the potential benefits of these dietary bioactive molecules for cognitive health and neuroprotection. This review will therefore summarise the current knowledge related to the impact of (poly)phenols on brain health presenting evidence from both epidemiological and clinical studies. Cellular and molecular mechanisms in relation to the observed effects will also be described, including their impact on the gut microbiota through the modulation of the gut-brain axis. Although (poly)phenols have the potential to modulate the gut-brain axis regulation and influence cognitive function and decline through their interactions with gut microbiota, anti-inflammatory and antioxidant properties, further research, including randomised controlled trials and mechanistic studies, is needed to better understand the underlying mechanisms and establish causal relationships between (poly)phenol intake and brain health.
（多）酚类是一组天然存在的植物化学物质，大量存在于植物性食品和饮料中，具有多种结构和活性。由于人们对这些膳食生物活性分子对认知健康和神经保护的潜在益处越来越感兴趣，（多）酚类对脑功能的影响已受到广泛关注。因此，本综述将总结与（多）酚类对脑健康影响相关的现有知识，呈现流行病学和临床研究的证据。还将描述与观察到的效应相关的细胞和分子机制，包括它们通过调节肠脑轴对肠道微生物群的影响。尽管（多）酚类有可能通过与肠道微生物群的相互作用、抗炎和抗氧化特性来调节肠脑轴调节并影响认知功能和衰退，但仍需要进一步研究，包括随机对照试验和机制研究，以更好地理解潜在机制并建立（多）酚类摄入量与脑健康之间的因果关系。
