聚二乙基乙烯基膦酸酯与新型荧光标记物的生物相容性研究。
Studies on the Biocompatibility of Poly(diethyl vinyl-phosphonate) with a New Fluorescent Marker.
机构信息
Wacker Chair of Macromolecular Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748, Garching, Germany.
Medizinische Klinik und Poliklinik IV, Nephrologisches Zentrum und Arbeitsgruppe Klinische Biochemie, Ludwig-Maximilians-Universität München, Schillerstraße 42, 80336, München, Germany.
出版信息
Macromol Rapid Commun. 2018 Aug;39(15):e1800259. doi: 10.1002/marc.201800259. Epub 2018 Jun 11.
Utilization of group transfer polymerization for the synthesis of poly(diethyl vinylphosphonate) (PDEVP) allows its controlled end-group functionalization. Thus, a new fluorescent chromophore/PDEVP conjugate is prepared and subjected to biocompatibility tests on two different human cell lines. In contrast to the previous studies, the tagged polymer is not absorbed by cells from the solution and has nearly no impact on cell mortality rate.
利用基团转移聚合来合成聚（二乙基乙烯基膦酸酯）（PDEVP）可以对其端基进行可控的功能化。因此，制备了一种新的荧光生色团/PDEVP 缀合物，并在两种不同的人细胞系上进行了生物相容性测试。与之前的研究不同，标记的聚合物不会从溶液中被细胞吸收，对细胞死亡率几乎没有影响。
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