Hsieh Shih-Rong, Chang Chi-Jung, Way Tzong-Der, Kwan Po-Cheung, Hung Tsung-Wei
Department of Surgery, Taichung Veterans General Hospital, Taichung 40724, Taiwan.
J Fluoresc. 2009 Jul;19(4):733-40. doi: 10.1007/s10895-009-0469-8. Epub 2009 Feb 12.
Comb-like PEMLn polymers with pendent PEG-PLLA side chains were synthesized as tissue anti-adhesion barriers. The comb-like structure improved the flexibility of the films. Fluorescent polymer-biocompatible polymer guest-host materials were printed on the films as marking dots. Without sacrificing rats on different days after surgery, degradation behaviors of the marked films can be investigated non-invasively in the in-vivo imaging system (IVIS) by monitoring the location of fluorescent signals. Degradation properties of PEML1/G26L35 films were adjusted by incorporating G26L35 oligomers. PEML1 and PEML1/G26L35 films were very effective in preventing post-surgical tissue-adhesions. Degradation behaviors of various films observed in the animal study were consistent with those investigated by the in-vivo imaging method. Fluorescent polymer/biocompatible polymer blends were promising candidates for in-vivo imaging applications.
合成了带有侧链聚乙二醇-聚乳酸（PEG-PLLA）的梳状聚（2-甲基丙烯酰氧乙基磷酰胆碱-co-月桂酸丙烯酸酯）（PEMLn）聚合物作为组织抗粘连屏障。梳状结构提高了薄膜的柔韧性。将荧光聚合物-生物相容性聚合物客体-主体材料作为标记点印刷在薄膜上。在术后不同天数不处死大鼠的情况下，通过监测荧光信号的位置，可在体内成像系统（IVIS）中对标记薄膜的降解行为进行无创研究。通过掺入G26L35低聚物来调节PEML1/G26L35薄膜的降解性能。PEML1和PEML1/G26L35薄膜在预防术后组织粘连方面非常有效。在动物研究中观察到的各种薄膜的降解行为与通过体内成像方法研究的结果一致。荧光聚合物/生物相容性聚合物共混物是体内成像应用的有前途的候选材料。
