Peng Zhihua, Wang Yilei, Yu Zhi, Zhao Dezhi, Song Linhua, Jiang Cuiyu
Department of Chemistry, College of Science , China University of Petroleum (East China) , Qingdao , Shandong 266580 , P. R. China.
J Org Chem. 2018 Aug 3;83(15):7900-7906. doi: 10.1021/acs.joc.8b00776. Epub 2018 Jun 20.
A novel C(sp)-H bond arylation of benzyl ethers with Knochel-type arylzinc reagents has been developed. This transition-metal-catalyst-free reaction proceeds well under mild conditions in a simple and effective manner and enables the synthesis of a wide range of potentially biologically active benzyl ethers by using highly functionalized organozinc reagents as a carbon nucleophile.
已开发出一种用克诺赫尔型芳基锌试剂对苄基醚进行新型C(sp)-H键芳基化反应。这种无过渡金属催化剂的反应在温和条件下以简单有效的方式顺利进行，并通过使用高度官能化的有机锌试剂作为碳亲核试剂，能够合成多种具有潜在生物活性的苄基醚。
