Shavit Y, Terman G W, Martin F C, Lewis J W, Liebeskind J C, Gale R P
J Immunol. 1985 Aug;135(2 Suppl):834s-837s.
Our results indicate that a particular form of footshock stress can suppress immune function in rats and decrease their resistance to tumor challenge. These effects appear to be mediated by opioid peptides released by stress, and they can be mimicked by high doses of morphine given systemically or by a vastly smaller dose delivered intracerebroventricularly. Such findings fit well into the emerging field of behavioral neuroimmunology and reinforce continuing efforts to elucidate the neural and neurohumoral mechanisms by which the environment can affect the organism's immune system.
我们的研究结果表明，一种特定形式的足部电击应激能够抑制大鼠的免疫功能，并降低它们对肿瘤攻击的抵抗力。这些效应似乎是由应激释放的阿片肽介导的，并且可以通过全身给予高剂量吗啡或脑室内给予剂量小得多的吗啡来模拟。这些发现与行为神经免疫学这一新兴领域非常契合，并加强了为阐明环境影响机体免疫系统的神经和神经体液机制而持续进行的努力。
