Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; email:
Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou 310058, China;
Annu Rev Anal Chem (Palo Alto Calif). 2018 Jun 12;11(1):265-286. doi: 10.1146/annurev-anchem-061417-125840.
This review summarizes progress in the fabrication, modification, characterization, and applications of nanopipettes since 2010. A brief history of nanopipettes is introduced, and the details of fabrication, modification, and characterization of nanopipettes are provided. Applications of nanopipettes in chemical analysis are the focus in several cases, including recent progress in imaging; in the study of single molecules, single nanoparticles, and single cells; in fundamental investigations of charge transfer (ion and electron) reactions at liquid/liquid interfaces; and as hyphenated techniques combined with other methods to study the mechanisms of complicated electrochemical reactions and to conduct bioanalysis.
本文综述了 2010 年以来纳米移液器的制造、修饰、表征和应用方面的进展。文中介绍了纳米移液器的简要历史，提供了纳米移液器的制造、修饰和表征的详细信息。在某些情况下，重点介绍了纳米移液器在化学分析中的应用，包括成像方面的最新进展；在单个分子、单个纳米粒子和单个细胞的研究；在液/液界面处电荷转移（离子和电子）反应的基础研究；以及作为与其他方法相结合的联用技术，用于研究复杂电化学反应的机制和进行生物分析。
