Takami Tomohide, Park Bae Ho, Kawai Tomoji
Division of Quantum Phases and Devices, Department of Physics, Konkuk University, Seoul, 143-701 Korea.
Nano Converg. 2014;1(1):17. doi: 10.1186/s40580-014-0017-3. Epub 2014 Apr 25.
Nanopipettes, with tip orifices on the order of tens to hundreds of nanometers, have been utilized in the fields of analytical chemistry and nanophysiology. Nanopipettes make nanofabrication possible at liquid/solid interfaces. Moreover, they are utilized in time-resolved measurements and for imaging biological materials, , living cells, by using techniques such as scanning ion-conductance microscopy and scanning electrochemical microscopy. We have successfully fabricated ion-selective nanopipettes that can be used to identify targeted ions such as sodium and potassium in- and outside of living cells. In this review, we discuss the extent of utilization of nanopipettes in investigating the nanoworld. In addition, we discuss the potential applications of future nanopipettes.
纳米吸管的尖端孔径在几十到几百纳米范围内，已被应用于分析化学和纳米生理学领域。纳米吸管使在液/固界面进行纳米制造成为可能。此外，通过使用扫描离子电导显微镜和扫描电化学显微镜等技术，它们被用于时间分辨测量和对生物材料、活细胞进行成像。我们已经成功制造出离子选择性纳米吸管，可用于识别活细胞内外的目标离子，如钠和钾。在这篇综述中，我们讨论了纳米吸管在探索纳米世界方面的应用程度。此外，我们还讨论了未来纳米吸管可能的应用。
