长期大剂量胺碘酮治疗期间的周围神经病变
Peripheral neuropathy during longterm high-dose amiodarone therapy.
作者信息
Fraser A G, McQueen I N, Watt A H, Stephens M R
出版信息
J Neurol Neurosurg Psychiatry. 1985 Jun;48(6):576-8. doi: 10.1136/jnnp.48.6.576.
Abstract
Three patients developed peripheral neuropathy after taking amiodarone for more than 18 months. All had high serum concentrations of amiodarone and its desethyl metabolite; in one patient concentrations in a sural nerve biopsy were 80 times higher than in serum. Peripheral neuropathy is a complication of large doses of amiodarone taken over long periods.
摘要
三名患者在服用胺碘酮超过18个月后出现周围神经病变。所有患者的胺碘酮及其去乙基代谢物血清浓度均较高；一名患者腓肠神经活检中的浓度比血清中高80倍。周围神经病变是长期服用大剂量胺碘酮的一种并发症。
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本文引用的文献
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Neuropathy and fatal hepatitis in a patient receiving amiodarone.一名服用胺碘酮的患者出现神经病变和致命性肝炎。
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