胺碘酮及其去乙基代谢物的高效液相色谱测定：方法与初步观察
High-performance liquid chromatographic measurement of amiodarone and its desethyl metabolite: methodology and preliminary observations.
作者信息
Storey G C, Holt D W, Holt P, Curry P V
出版信息
Ther Drug Monit. 1982;4(4):385-8. doi: 10.1097/00007691-198212000-00009.
Abstract
A high-performance liquid chromatographic technique is described for the measurement of amiodarone and its desethyl metabolite in plasma. Preliminary observations are presented on the concentrations of metabolite found during the early stages of chronic amiodarone therapy. A case history is outlined in which noncompliance during treatment with amiodarone was confirmed by measurement of the ratio of desethylamiodarone to amiodarone concentrations.
摘要
描述了一种用于测定血浆中胺碘酮及其去乙基代谢物的高效液相色谱技术。给出了在慢性胺碘酮治疗早期发现的代谢物浓度的初步观察结果。概述了一个病例史，其中通过测量去乙基胺碘酮与胺碘酮浓度之比证实了胺碘酮治疗期间的不依从性。
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