Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, United States of America.
PLoS One. 2018 Jun 12;13(6):e0198995. doi: 10.1371/journal.pone.0198995. eCollection 2018.
The relations of physical activity and sedentary behavior to mortality risk among patients with renal cell cancer have not yet been evaluated.
We conducted a prospective cohort study among 667 renal cell cancer survivors aged 50-71 years of the National Institutes of Health (NIH)-AARP Diet and Health Study with a median follow-up time of 7.1 years. Post-diagnosis physical activity, TV viewing, and total sitting time were assessed using self-administered questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were estimated using Cox proportional hazards models.
Increasing levels of moderate to vigorous physical activity were related to decreased risk of overall mortality [multivariable-adjusted HRs for <1 hr/wk (reference), 1 to 3 hrs/wk, ≥3 to <7 hrs/wk, and ≥7 hrs/wk = 1.0, 1.16, 0.94, and 0.60 (95% CI = 0.38-0.96; p-trend = 0.03)]. In contrast, television viewing was associated with increased risk of overall mortality in the age- and sex-adjusted model (HR for >4 hrs/d vs. 0 to 2 hrs/d = 1.52, 95% CI = 1.02-2.26; p-trend = 0.04), but the relation was attenuated following further control for other covariates (multivariable-adjusted HR = 1.44, 95% CI = 0.92-2.24; p-trend = 0.11). Total sitting time was unrelated to all-cause mortality.
Among renal cancer patients, moderate to vigorous physical activity is associated with decreased risk of overall mortality. Clinicians should consider discussing the potential benefits of physical activity for longevity among survivors of renal cell cancer.
体力活动和久坐行为与肾细胞癌患者的死亡风险之间的关系尚未得到评估。
我们对美国国立卫生研究院（NIH）-AARP 饮食与健康研究中的 667 名年龄在 50-71 岁的肾细胞癌幸存者进行了一项前瞻性队列研究，中位随访时间为 7.1 年。使用自我管理问卷评估诊断后体力活动、看电视和总坐姿时间。使用 Cox 比例风险模型估计死亡率的风险比（HRs）和 95%置信区间（CIs）。
中等到剧烈体力活动水平的增加与总死亡率降低相关[多变量调整后的 HRs 为<1 小时/周（参考）、1-3 小时/周、≥3-<7 小时/周和≥7 小时/周=1.0、1.16、0.94 和 0.60（95%CI=0.38-0.96；p 趋势=0.03）]。相比之下，在年龄和性别调整模型中，看电视与总死亡率的增加相关（>4 小时/天与 0-2 小时/天的 HR=1.52，95%CI=1.02-2.26；p 趋势=0.04），但在进一步控制其他协变量后，这种关系减弱（多变量调整后的 HR=1.44，95%CI=0.92-2.24；p 趋势=0.11）。总坐姿时间与全因死亡率无关。
在肾细胞癌患者中，中等到剧烈的体力活动与总死亡率降低相关。临床医生应考虑讨论体力活动对肾细胞癌幸存者长寿的潜在益处。
