Dyadyk A I, Efremenko V A, Kugler T E, Maltseva N V, Prykolota O A
"M. Gorky Donetsk National Medical University" of the Ukraine Ministry of Health Care.
Kardiologiia. 2018(S5):13-19.
In recent years there has been a marked decrease in cardiac glycosides use in patients with heart failure in sinus rhythm and atrial fibrillation. The results of published studies contradict each other. Some of them doubt the favorable effect of digoxin in patients with heart failure; others refute the increase in the lethality and frequency of hospitalizations associated with the use of digoxin. In this regard, we found it important to analyze these reports impartially and reflect modern views on the mechanisms of cardiac glycosides, the pharmacokinetics and the possibility of optimizing digitalis therapy in cardiac practice.
近年来，窦性心律和心房颤动的心力衰竭患者使用强心苷的情况显著减少。已发表研究的结果相互矛盾。其中一些研究怀疑地高辛对心力衰竭患者的有益作用；另一些研究则反驳了使用地高辛会增加致死率和住院频率的观点。在这方面，我们认为公正地分析这些报告并反映关于强心苷作用机制、药代动力学以及在心脏实践中优化洋地黄治疗可能性的现代观点很重要。
