Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Colombian Collaborative Network of Zika, Chikungunya and Other Arboviruses (RECOLZIKA), Pereira, Risaralda, Colombia; Infection and Immunity Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Medical School, Faculty of Health Sciences, UniFranz, Cochabamba, Bolivia.
Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Colombian Collaborative Network of Zika, Chikungunya and Other Arboviruses (RECOLZIKA), Pereira, Risaralda, Colombia; Infection and Immunity Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia.
Travel Med Infect Dis. 2018 Sep-Oct;25:20-25. doi: 10.1016/j.tmaid.2018.06.006. Epub 2018 Jun 9.
Zika virus (ZIKV) infection has emerged as a significant threat for pregnant women and newborns in populations living in or visiting Latin America. We previously reported a preliminary analysis in Sucre, Colombia, as the first group of pregnant women with RT-PCR-confirmed ZIKV (ZIKa enEmbarazadas yReciénNacidos enCOLombia, ZIKERNCOL).
In this second report, findings of the first 86 pregnant women from La Virginia and Dosquebradas (municipalities), Risaralda, Colombia, with RT-PCR-confirmed ZIKV infection are reported. Clinical, demographical and obstetrical findings are described.
All women reported ZIKV symptoms during pregnancy: 79.1% rash, 55.8% fever, among others. In addition to ZIKV, RT-PCR was positive for dengue in 18.6%; 45.3% Dengue IgM+; 5.8% RT-PCR positive for chikungunya; 3.6% Chikungunya IgM+. STORCH screening in mother: 11.6% IgG + anti-Toxoplasma gondii, 6% IgG + anti-rubella, 4.7% IgG + CMV. The rest of STORCH tests were negative. Microcephaly was observed in 2.4% of the newborns. No calcifications or other CNS alterations were detected. One newborn had cleft palate and one had bilateral renal ectopy.
The rate of microcephaly in our cohort was consistent with other studies. Pregnant women in endemic areas should be followed and tested according to standard protocols, and asymptomatic ZIKV infection should be considered. Long-term follow-up of children is required in the congenital Zika syndrome (CZS) assessment.
寨卡病毒（ZIKV）感染已成为拉丁美洲居住或访问的孕妇和新生儿的重大威胁。我们之前曾报道过哥伦比亚苏克雷的初步分析，这是第一组经 RT-PCR 确诊的寨卡病毒（ZIKa enEmbarazadas yReciénNacidos enCOLombia，ZIKERNCOL）孕妇。
在本报告的第二部分，我们报告了哥伦比亚里萨拉尔达省拉弗拉维亚和多斯奎布拉达斯（市镇）的前 86 名经 RT-PCR 确诊的寨卡病毒感染孕妇的结果。描述了临床、人口统计学和产科发现。
所有孕妇均报告了怀孕期间的寨卡病毒症状：皮疹 79.1%，发热 55.8%等。除了寨卡病毒外，18.6%的 RT-PCR 检测结果还为登革热阳性；45.3%的登革热 IgM+；5.8%的 RT-PCR 检测结果为基孔肯雅热阳性；3.6%的基孔肯雅热 IgM+。母亲的 STORCH 筛查：11.6% IgG+抗弓形虫，6% IgG+抗风疹，4.7% IgG+CMV。其余的 STORCH 检测均为阴性。新生儿中观察到小头畸形的比例为 2.4%。未发现钙化或其他中枢神经系统改变。一个新生儿有腭裂，一个有双侧肾异位。
我们的队列中小头畸形的发生率与其他研究一致。应根据标准方案对流行地区的孕妇进行随访和检测，并应考虑无症状的寨卡病毒感染。在先天性寨卡病毒综合征（CZS）评估中需要对儿童进行长期随访。
