Innovative Green Product Synthesis and Renewable Environment Development Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Centre for Rural Development and Technology, Indian Institute of Technology Delhi, HauzKhas, New Delhi, Delhi, 110016, India.
Microb Pathog. 2018 Sep;122:84-89. doi: 10.1016/j.micpath.2018.06.016. Epub 2018 Jun 9.
Pathogenic microbes are becoming a potential threat to human beings and environment. Owing to the biofilm forming ability, multidrug resistant pathogens have emerged, which has led to increased death and mortality rate. CuO is a transition metal oxide with high captivating property used for various technological applications such as superconductors, gas sensors, photocatalytic applications etc. CuO in the form of nanoparticles (NPs) is a potential candidate against microbial pathogens. Recently, the antimicrobial and antibiofilm properties of CuO have been tested against various pathogenic bacteria and fungi. In the present study, Fe doped CuO synthesized using sol-gel method was tested against pathogenic bacteria and fungus. The synthesized NPs were characterized using XRD, FTIR, SEM and EDAX analysis. The photocatalytic activity of the Fe doped CuO NPs was analysed using UV-Vis and fluorescent light spectroscopic analysis (FL). In vitro analysis was performed to analyze the antimicrobial and antibiofilm potentials of Fe doped CuO NPs against the pathogenic bacteria (Staphylococcus aureus and Staphylococcus epidermidis) and fungus (Candida albicans). Therefore, the present study is the first report showing both antibiofilm and antibacterial activities of Fe doped CuO NPs against bacterial and fungal pathogens.
致病微生物对人类和环境构成了潜在威胁。由于生物膜形成能力，多药耐药病原体已经出现，这导致死亡率和死亡率上升。氧化铜是一种具有高捕获特性的过渡金属氧化物，用于各种技术应用，如超导体、气体传感器、光催化应用等。纳米颗粒（NPs）形式的氧化铜是一种针对微生物病原体的潜在候选物。最近，氧化铜的抗菌和抗生物膜特性已经针对各种致病菌和真菌进行了测试。在本研究中，使用溶胶-凝胶法合成了掺铁氧化铜，并对其进行了测试，以对抗致病菌和真菌。使用 XRD、FTIR、SEM 和 EDAX 分析对合成的 NPs 进行了表征。使用紫外可见分光光度计和荧光分光光度计（FL）分析对掺铁氧化铜 NPs 的光催化活性进行了分析。体外分析用于分析掺铁氧化铜 NPs 对致病菌（金黄色葡萄球菌和表皮葡萄球菌）和真菌（白色念珠菌）的抗菌和抗生物膜潜力。因此，本研究首次报道了掺铁氧化铜 NPs 对细菌和真菌病原体的抗生物膜和抗菌活性。
