Department of Chemistry, University of Coimbra, Rua Larga, 3004-535, Portugal.
Photodiagnosis Photodyn Ther. 2018 Sep;23:75-77. doi: 10.1016/j.pdpdt.2018.06.009. Epub 2018 Jun 15.
Photodynamic therapy (PDT) initiates with the absorption of light, which depend on the spectral overlap between the light source emission and the photosensitizer absorption, resulting in the number of photons absorbed, the key parameter starting PDT processes. Most papers report light doses regardless if the light is only partially absorbed or shifted relatively to the absorption peak, misleading the actual light dose value and not allowing quantitative comparisons between photosensitizers and light sources. In this manuscript a method is presented to calculate the actual light dose delivered by any light source for a given photosensitizer. This method allows comparing light doses delivered for any combination of light source (broad or narrow band or daylight) and photosensitizer.
光动力疗法（PDT）始于光的吸收，这取决于光源发射光谱与光敏剂吸收光谱之间的重叠，从而决定了吸收的光子数量，这是启动 PDT 过程的关键参数。大多数论文报告的光剂量都没有考虑到光是否只是部分吸收或相对于吸收峰发生偏移，这会误导实际的光剂量值，并且无法在光敏剂和光源之间进行定量比较。在本文中，提出了一种方法来计算给定光敏剂的任何光源的实际光剂量。该方法允许比较任何光源（宽带或窄带或日光）和光敏剂组合所传递的光剂量。
