Wang Kai, Yu Boxin, Pathak Janak L
International Medicine Center, Tianjin Hospital, 406 south of JieFang road, HeXi District, Tianjin, China.
Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou 510182, China.
J Cancer. 2021 Jan 1;12(4):1154-1160. doi: 10.7150/jca.51537. eCollection 2021.
Lung cancer is one of the leading causes of cancer-related death worldwide, with nearly 1.8 million-diagnosis and 1.59 million deaths. Surgery, radiotherapy, and chemotherapy in individual or combination are commonly used to treat lung cancers. Photodynamic therapy (PDT) is a highly selective method for the destruction of cancer cells by exerting cytotoxic activity on malignant cells. PDT has been the subject of numerous clinical studies and has proven to be an effective strategy for cancer therapy. Clinical studies revealed that PDT could prolong survival in patients with inoperable cancers and significantly improve quality of life. For inoperable lung cancer cases, PDT could be an effective therapy. Despite the clinical success reported, PDT is still currently underutilized to treat lung cancer and other tumors. PTD is still a new treatment approach for lung cancer mainly due to the lack of enough clinical research evaluating its' effectiveness and side effects. In this review, we discuss the current prospects and future potentials of PDT in lung cancer treatment.
肺癌是全球癌症相关死亡的主要原因之一，每年有近180万例诊断病例和159万例死亡病例。单独或联合使用手术、放疗和化疗通常用于治疗肺癌。光动力疗法（PDT）是一种通过对恶性细胞发挥细胞毒活性来高度选择性地破坏癌细胞的方法。PDT一直是众多临床研究的主题，并已被证明是一种有效的癌症治疗策略。临床研究表明，PDT可以延长无法手术切除的癌症患者的生存期，并显著提高生活质量。对于无法手术切除的肺癌病例，PDT可能是一种有效的治疗方法。尽管有临床成功的报道，但PDT目前在治疗肺癌和其他肿瘤方面仍未得到充分利用。PTD仍然是一种治疗肺癌的新方法，主要是因为缺乏足够的临床研究来评估其有效性和副作用。在这篇综述中，我们讨论了PDT在肺癌治疗中的当前前景和未来潜力。
