通过聚合诱导相分离方法制备的具有Janus 结构的粒子同时释放两种药物。
Simultaneous two drugs release form Janus particles prepared via polymerization-induced phase separation approach.
机构信息
Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
出版信息
Colloids Surf B Biointerfaces. 2018 Oct 1;170:85-91. doi: 10.1016/j.colsurfb.2018.05.067. Epub 2018 Jun 1.
Seeded emulsion polymerization of 2-dimethylaminoethylamino methacrylate (DMAEMA) was carried out using monodispersed poly(2-hydroxyehtyl methacrylate) (PHEMA) seeds to produce Janus particles. Three feeding approaches were used comprising one together, rest and continuous feeding methods to investigate different morphologies. However, FE-SEM results showed that all feeding approaches yielded dumbbell-like Janus particles. Furthermore, snowman-like Janus particles were obtained via seeded distillation precipitation polymerization (DPP). It is shown that minimizing the total interfacial free energy alongside difference in solubility parameters of Janus domains are responsible for obtained morphologies. Two different morphologies (dumbbell-like and snowman-like) were chosen as carriers of ibuprofen and DOX simultaneously. Also, simultaneous release of two drugs were investigated in different conditions. Dumbbell-like Janus particles showed higher ibuprofen loading whereas DOX was more loaded onto snowman-like Janus particles. Also, DOX was released more rapidly through Janus particles at different pH values and both types of Janus particles showed similar drugs release behaviors.
采用单分散聚（2-羟乙基甲基丙烯酸酯）（PHEMA）种子进行 2-二甲氨基乙基氨基甲基丙烯酸酯（DMAEMA）的种子乳液聚合，以制备两亲性粒子。使用了三种进料方法，包括一起进料、间歇进料和连续进料方法，以研究不同的形态。然而，FE-SEM 结果表明，所有进料方法都得到了哑铃型两亲性粒子。此外，通过种子蒸馏沉淀聚合（DPP）得到了雪人型两亲性粒子。结果表明，最小化总界面自由能以及两亲性域之间溶解度参数的差异是获得这些形态的原因。选择了两种不同的形态（哑铃型和雪人型）作为布洛芬和 DOX 的载体。同时，在不同条件下研究了两种药物的同时释放。哑铃型两亲性粒子具有较高的布洛芬负载量，而 DOX 则更多地负载在雪人型两亲性粒子上。此外，在不同的 pH 值下，通过两亲性粒子快速释放 DOX，并且两种类型的两亲性粒子都表现出相似的药物释放行为。
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