Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Colloids Surf B Biointerfaces. 2019 Jan 1;173:155-163. doi: 10.1016/j.colsurfb.2018.09.068. Epub 2018 Sep 29.
Most recent studies on Janus particles have concentrated on amphiphilic Janus particles. Herein, a facile and efficient method based on polymerization-induced phase separation is presented to fabricate Janus particles with different morphologies. Theses novel hydrophilic Janus particles with two distinct hydrophilic domains have been prepared by combination of distillation precipitation polymerization (DPP) and seeded emulsion polymerization. Crosslinked poly(2-hydroxyehtyl methacrylate) (PHEMA) cores were synthesized via DPP and used as seed particles. Also, methacrylic acid (MAA) was used as second hydrophilic monomer. Effect of feeding approach, and reaction medium were investigated on the morphology of fabricated composite particles. Different morphologies such as cauliflower-like, dumbbell-like, and core-shell toward cauliflower-like structures were obtained by varying feeding approach and polymerization medium. The morphology of resultant particles was observed by means of FE-SEM and TEM images and their particle sizes were confirmed by DLS. Fabricated composite particles were used to simultaneously carry both DOX and ibuprofen. Drug release studies showed that Janus particles can be used in loading and release of two drugs simultaneously. However, release behaviors of DOX and ibuprofen were different at different pH values. Also, release behavior was significantly affected by the structure of composite particles.
最近对 Janus 粒子的研究集中在两亲性 Janus 粒子上。本文提出了一种基于聚合诱导相分离的简便高效的方法，用于制备具有不同形貌的 Janus 粒子。通过蒸馏沉淀聚合 (DPP) 和种乳液聚合相结合，制备了具有两个不同亲水区域的新型亲水 Janus 粒子。通过 DPP 合成交联的聚(2-羟乙基甲基丙烯酸酯) (PHEMA) 核作为种子颗粒。此外，还使用甲基丙烯酸 (MAA) 作为第二亲水性单体。考察了进料方式和反应介质对复合粒子形貌的影响。通过改变进料方式和聚合介质，可以得到不同的形貌，如菜花状、哑铃状和核壳状向菜花状结构。通过 FE-SEM 和 TEM 图像观察所得粒子的形态，并通过 DLS 确认其粒径。制备的复合粒子可同时携带 DOX 和布洛芬两种药物。药物释放研究表明，Janus 粒子可用于同时装载和释放两种药物。然而，在不同 pH 值下，DOX 和布洛芬的释放行为不同。此外，复合粒子的结构对释放行为有显著影响。
