Faculty of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Faculty of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Colloids Surf B Biointerfaces. 2020 Jul;191:111008. doi: 10.1016/j.colsurfb.2020.111008. Epub 2020 Apr 7.
Cross-liked poly(2-hydroxyethyl methacrylate-co-methacrylic acid) seeds with different morphologies such as cauliflower-like, lobed spherical, and spherical were used in seeded emulsion polymerization (SEP) of 2-(dimethylamino)ethyl methacrylate (DMAEMA), 2-hydroxyethyl methacrylate (HEMA), and methacrylic acid (MAA). The morphological structure of produced composite particles was observed using field emission scanning electron microscopy (FE-SEM). The origin of the formation of different morphologies was discussed using various thermodynamic parameters such as solubility parameters and intermolecular forces between polymeric components involved. Also, the effect of the morphology of seed particles on the resultant structures was investigated. Results showed that morphology of fabricated composite particles is induced from morphology of seed particles with larger sizes. Finally, the fabricated composite particles were utilized in the controlled release of DOX. The effect of morphological changes of synthesized composite particles on the cumulative release behavior at acidic environment indicated the pH-sensitive nature of drug release through carriers. The particles with PDMAEMA shell showed the highest release of DOX at pH = 7.4 whereas PMAA shells displayed the least cumulative release. Inversely, the lowest cumulative release at pH = 1.2 was shown by PDMAEMA-coated carriers. Moreover, particles with spherical morphology had better drug release than cauliflower-like ones originated from smart nature of carriers.
采用具有不同形态（如花椰菜状、叶状球形和球形）的交联聚（2-羟乙基甲基丙烯酸酯-共-甲基丙烯酸）种子进行 2-（二甲氨基）乙基甲基丙烯酸酯（DMAEMA）、2-羟乙基甲基丙烯酸酯（HEMA）和甲基丙烯酸（MAA）的种乳液聚合（SEP）。使用场发射扫描电子显微镜（FE-SEM）观察所得复合粒子的形态结构。通过涉及聚合成分之间的溶解度参数和分子间力等各种热力学参数讨论了不同形态形成的原因。还研究了种子粒子的形态对所得结构的影响。结果表明，复合粒子的形态是由较大尺寸的种子粒子的形态诱导形成的。最后，将合成的复合粒子用于 DOX 的控制释放。合成复合粒子形态变化对酸性环境下累积释放行为的影响表明了载体中药物通过释放的 pH 敏感性。具有 PDMAEMA 壳的粒子在 pH=7.4 时显示出 DOX 的最高释放，而 PMAA 壳显示出最低的累积释放。相反，在 pH=1.2 时 PDMAEMA 涂层载体显示出最低的累积释放。此外，源于载体的智能性质，具有球形形态的粒子比花椰菜状的粒子具有更好的药物释放。
