Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Colloids Surf B Biointerfaces. 2018 Oct 1;170:578-587. doi: 10.1016/j.colsurfb.2018.06.064. Epub 2018 Jun 30.
Composite particles with two individual hydrophilic parts were synthesized via seeded emulsion polymerization. As first part, nearly-monodisperse ethylene glycol dimethacrylate (EGDMA)-crosslinked poly(acrylic acid) (PAA) particles were synthesized by distillation precipitation polymerization (DPP). These particles were used as seeds in emulsion polymerization of 2-(dimethylamino)ethyl methacrylate (DMAEMA). Effects of type of surfactant, monomers/seed weight ratio and amount of shell crosslinker on the synthesized composite particles' morphology were studied. Different morphologies consisting of core-shell, Janus type, raspberry-like and porous core-shell structures were investigated by variations of polymerization parameters. Different structures were chosen as drug carriers and subjected to DOX loading and release system. Results showed that amount of drug loading and extent of release were strongly dependent on the structure of carriers whereas for all carriers, DOX was released more rapid. Kinetics of release was evaluated by different mathematical models to investigate the release mechanism through composite particles. Results showed that only Korsmeyer-Peppas model fitted the drug release data and other ones were inappropriate in this field.
通过种子乳液聚合合成了具有两个独立亲水部分的复合粒子。首先，通过蒸馏沉淀聚合（DPP）合成了近乎单分散的乙二醇二甲基丙烯酸酯（EGDMA）交联的聚（丙烯酸）（PAA）粒子。这些粒子被用作 2-（二甲氨基）乙基甲基丙烯酸酯（DMAEMA）乳液聚合的种子。研究了表面活性剂类型、单体/种子重量比和壳交联剂用量对合成复合粒子形态的影响。通过聚合参数的变化，研究了不同形态的核壳、Janus 型、覆盆子状和多孔核壳结构。选择不同的结构作为药物载体，并进行 DOX 负载和释放系统。结果表明，药物负载量和释放程度强烈依赖于载体的结构，而对于所有载体，DOX 的释放速度都更快。通过不同的数学模型评估释放动力学，以研究通过复合粒子的释放机制。结果表明，只有 Korsmeyer-Peppas 模型适合药物释放数据，而其他模型在该领域不适用。
