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骨质疏松症与恶性肿瘤:危险的组合。

Osteoporosis and malignancy: a dicey combination.

作者信息

Lakshmana Perumal Nandhini, Selvi Jayakumar, Sahoo Jaya Prakash, Kamalanathan Sadishkumar

机构信息

Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

出版信息

BMJ Case Rep. 2018 Jun 11;2018:bcr-2017-223881. doi: 10.1136/bcr-2017-223881.

Abstract

Osteoporosis is the most common metabolic bone disorder worldwide, especially in women. Postmenopausal status is the most common risk factor for osteoporosis in elderly women. The operational diagnosis of osteoporosis is usually made with the help of central dual energy X-ray absorptiometry scan. Clinically, osteoporosis is suspected in the background of one or more fractures of the hip, vertebra, proximal humerus or pelvis in the absence of local disease or high-energy trauma. Serious underlying illness can present with vertebral fractures and can be missed if other clues from clinical examination and investigations are overlooked. We report a case emphasising this aspect.

摘要

骨质疏松症是全球最常见的代谢性骨病,尤其是在女性中。绝经后状态是老年女性骨质疏松症最常见的危险因素。骨质疏松症的诊断通常借助于中央双能X线吸收测定扫描。临床上,在没有局部疾病或高能创伤的情况下,若出现髋部、脊椎、肱骨近端或骨盆一处或多处骨折,则怀疑患有骨质疏松症。严重的基础疾病可能表现为椎体骨折,如果忽视临床检查和调查中的其他线索,可能会漏诊。我们报告了一个强调这方面的病例。

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本文引用的文献

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Bone Metastases: An Overview.骨转移:概述
Oncol Rev. 2017 May 9;11(1):321. doi: 10.4081/oncol.2017.321. eCollection 2017 Mar 3.
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Denosumab for treatment of hypercalcemia of malignancy.地诺单抗用于治疗恶性肿瘤引起的高钙血症。
J Clin Endocrinol Metab. 2014 Sep;99(9):3144-52. doi: 10.1210/jc.2014-1001. Epub 2014 Jun 10.
7
Recognizing and treating secondary osteoporosis.识别和治疗继发性骨质疏松症。
Nat Rev Rheumatol. 2012 Aug;8(8):480-92. doi: 10.1038/nrrheum.2012.93. Epub 2012 Jul 10.
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Hypercalcemic crisis.高钙血症危象
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