Falcicchia Chiara, Simonato Michele, Verlengia Gianluca
Department of Medical Sciences, Section of Pharmacology, and Neuroscience Center, University of Ferrara and National Institute of Neuroscience, Ferrara, Italy.
School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.
Front Cell Neurosci. 2018 May 29;12:147. doi: 10.3389/fncel.2018.00147. eCollection 2018.
One third of the epilepsies are refractory to conventional antiepileptic drugs (AEDs) and, therefore, identification of new therapies is highly needed. Here, we briefly describe two approaches, direct cell grafting and gene therapy, that may represent alternatives to conventional drugs for the treatment of focal epilepsies. In addition, we discuss more in detail some new tools, cell based-biodelivery systems (encapsulated cell biodelivery (ECB) devices) and new generation gene therapy vectors, which may help in the progress toward clinical translation. The field is advancing rapidly, and there is optimism that cell and/or gene therapy strategies will soon be ready for testing in drug-resistant epileptic patients.
三分之一的癫痫患者对传统抗癫痫药物（AEDs）耐药，因此，迫切需要找到新的治疗方法。在此，我们简要介绍两种可能替代传统药物治疗局灶性癫痫的方法，即直接细胞移植和基因治疗。此外，我们将更详细地讨论一些新工具，基于细胞的生物递送系统（封装细胞生物递送（ECB）装置）和新一代基因治疗载体，它们可能有助于推动临床转化进程。该领域发展迅速，人们乐观地认为细胞和/或基因治疗策略很快将准备好在耐药癫痫患者中进行测试。
