Graziane Nicholas M, Neumann Peter A, Dong Yan
Departments of Anesthesiology and Perioperative Medicine and Pharmacology, Penn State College of Medicine, Hershey, PA, United States.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States.
Front Synaptic Neurosci. 2018 May 29;10:12. doi: 10.3389/fnsyn.2018.00012. eCollection 2018.
The lateral habenula (LHb) regulates reward learning and controls the updating of reward-related information. Drugs of abuse have the capacity to hijack the cellular and neurocircuit mechanisms mediating reward learning, forming non-adaptable, compulsive behaviors geared toward obtaining illicit substances. Here, we discuss current findings demonstrating how drugs of abuse alter intrinsic and synaptic LHb neuronal function. Additionally, we discuss evidence for how drug-induced LHb alterations may affect the ability to predict reward, potentially facilitating an addiction-like state. Altogether, we combine and results for an overview of how drugs of abuse alter LHb function and how these functional alterations affect the ability to learn and update behavioral responses to hedonic external stimuli.
外侧缰核（LHb）调节奖赏学习并控制奖赏相关信息的更新。滥用药物能够劫持介导奖赏学习的细胞和神经回路机制，形成旨在获取非法物质的不适应、强迫性行为。在此，我们讨论当前的研究结果，这些结果表明滥用药物如何改变LHb神经元的内在和突触功能。此外，我们还讨论了药物诱导的LHb改变可能如何影响预测奖赏的能力，从而可能促进成瘾样状态的证据。总之，我们综合各项结果，概述滥用药物如何改变LHb功能，以及这些功能改变如何影响学习和更新对享乐性外部刺激的行为反应的能力。
