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糖皮质激素受体调节

Glucocorticoid receptor regulation.

作者信息

Svec F

出版信息

Life Sci. 1985 Jun 24;36(25):2359-66. doi: 10.1016/0024-3205(85)90339-x.

DOI:10.1016/0024-3205(85)90339-x
PMID:2989635
Abstract

Glucocorticoids, like other classes of steroid hormones, must bind to cellular receptors in order to exert their effects. Because of this central role in mediating hormone action, it is important to elucidate those factors that control receptor content. The purpose of this minireview is to summarize the recent work that explores the mechanisms through which cells modulate their glucocorticoid receptor binding capacity.

摘要

糖皮质激素与其他类固醇激素一样,必须与细胞受体结合才能发挥作用。由于其在介导激素作用中发挥核心作用,阐明控制受体含量的因素很重要。本综述的目的是总结最近探索细胞调节其糖皮质激素受体结合能力机制的研究工作。

相似文献

1
Glucocorticoid receptor regulation.糖皮质激素受体调节
Life Sci. 1985 Jun 24;36(25):2359-66. doi: 10.1016/0024-3205(85)90339-x.
2
Heterogeneity of glucocorticoid receptors.糖皮质激素受体的异质性。
Circ Res. 1980 Jun;46(6 Pt 2):I83-7.
3
Steroid hormone actions in tissue culture cells and cell hybrids--their relation to human malignancies.类固醇激素在组织培养细胞和细胞杂交体中的作用——它们与人类恶性肿瘤的关系。
Recent Prog Horm Res. 1976;33:571-615. doi: 10.1016/b978-0-12-571133-3.50020-9.
4
Glucocorticoid binding and control ACTH secretion.糖皮质激素结合并控制促肾上腺皮质激素的分泌。
J Physiol (Paris). 1981 Mar;77(8):923-33.
5
Dissociation between the magnitude of nuclear binding and the biopotency of glucocorticoids.核结合强度与糖皮质激素生物活性之间的解离。
Endocrinology. 1982 Aug;111(2):699-702. doi: 10.1210/endo-111-2-699.
6
Variations in cellular sensitivity to glucocorticoids: observations and mechanisms.细胞对糖皮质激素敏感性的差异:观察结果与机制
Monogr Endocrinol. 1979;12:423-48. doi: 10.1007/978-3-642-81265-1_23.
7
Glucocorticoid receptors: ATP and cell cycle dependence, phosphorylation, and hormone resistance.
Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 2):S2-6. doi: 10.1164/ajrccm/154.2_Pt_2.S2.
8
Role and regulation of brain glucocorticoid receptors.脑糖皮质激素受体的作用与调控
Pharmacol Res Commun. 1980 Mar;12(3):283-92. doi: 10.1016/s0031-6989(80)80014-2.
9
Glucocorticoid-dependent maintenance of CYP2C11-dependent oxidation in male rat liver in vivo.雄性大鼠肝脏中细胞色素P450 2C11依赖性氧化的糖皮质激素依赖性体内维持。
Hum Exp Toxicol. 2000 Feb;19(2):126-31. doi: 10.1191/096032700678815648.
10
Possible mechanisms for the permissive action of glucocorticoid hormones: studies on cyclic AMP-dependent protein kinase activity of rat liver and of mouse L1210 cells.糖皮质激素允许作用的可能机制:对大鼠肝脏和小鼠L1210细胞环磷酸腺苷依赖性蛋白激酶活性的研究
J Steroid Biochem. 1976 Nov-Dec;7(11-12):1131-4. doi: 10.1016/0022-4731(76)90044-3.

引用本文的文献

1
Glucocorticoid receptor BclI polymorphism associates with immunomodulatory response to stress hormone in human peripheral blood mononuclear cells.糖皮质激素受体 BclI 多态性与人类外周血单个核细胞对应激激素的免疫调节反应有关。
Int J Immunogenet. 2013 Jun;40(3):222-9. doi: 10.1111/iji.12018. Epub 2012 Nov 23.
2
Increased glucocorticoid receptor expression and activity mediate the LPS resistance of SPRET/EI mice.糖皮质激素受体表达和活性的增加介导了 SPRET/EI 小鼠对 LPS 的抵抗。
J Biol Chem. 2010 Oct 1;285(40):31073-86. doi: 10.1074/jbc.M110.154484. Epub 2010 Jul 27.
3
Characterization of a novel gain of function glucocorticoid receptor knock-in mouse.
一种新型功能获得性糖皮质激素受体敲入小鼠的特征描述。
J Biol Chem. 2009 Mar 6;284(10):6249-59. doi: 10.1074/jbc.M807997200. Epub 2008 Nov 18.
4
The modulation of glucocorticoid receptor content by 3-O-methyl-D-glucose transport in human mononuclear leukocyte in obesity.肥胖状态下人单核白细胞中3-O-甲基-D-葡萄糖转运对糖皮质激素受体含量的调节作用
J Endocrinol Invest. 1998 Nov;21(10):656-61. doi: 10.1007/BF03350794.
5
Differential effect of glucocorticoids on tumour necrosis factor production in mice: up-regulation by early pretreatment with dexamethasone.糖皮质激素对小鼠肿瘤坏死因子产生的不同作用:地塞米松早期预处理的上调作用
Clin Exp Immunol. 1994 Apr;96(1):166-9. doi: 10.1111/j.1365-2249.1994.tb06247.x.
6
Glucocorticoid receptors in mononuclear blood cells and their correlation to endogenous and exogenous corticoids in healthy and asthmatic children.健康及哮喘儿童单核血细胞中的糖皮质激素受体及其与内源性和外源性皮质激素的相关性
Eur J Pediatr. 1988 Jun;147(5):490-5. doi: 10.1007/BF00441973.
7
Number of glucocorticoid receptors in lymphocytes and their sensitivity to hormone action.淋巴细胞中糖皮质激素受体的数量及其对激素作用的敏感性。
Experientia. 1989 Dec 1;45(11-12):1115-7. doi: 10.1007/BF01950174.
8
The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites.人类糖皮质激素受体基因的启动子及首个非翻译外显子富含GC,但缺乏共有糖皮质激素受体元件位点。
Mol Cell Biol. 1990 Oct;10(10):5580-5. doi: 10.1128/mcb.10.10.5580-5585.1990.
9
Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone.甲状腺激素对大鼠多种c-erbA信使核糖核酸种类的差异及组织特异性调控
J Clin Invest. 1990 Jan;85(1):101-5. doi: 10.1172/JCI114398.
10
Receptor-mediated methylprednisolone pharmacodynamics in rats: steroid-induced receptor down-regulation.大鼠中受体介导的甲基泼尼松龙药效学:类固醇诱导的受体下调。
J Pharmacokinet Biopharm. 1992 Aug;20(4):333-55. doi: 10.1007/BF01062462.