人类糖皮质激素受体基因的启动子及首个非翻译外显子富含GC，但缺乏共有糖皮质激素受体元件位点。
The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites.
作者信息
Zong J, Ashraf J, Thompson E B
机构信息
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550.
出版信息
Mol Cell Biol. 1990 Oct;10(10):5580-5. doi: 10.1128/mcb.10.10.5580-5585.1990.
Abstract
Glucocorticoid receptor mRNA is regulated by glucocorticoids. We found no consensus glucocorticoid response element, TATA box, or CAAT box but many GC boxes in approximately 3 kilobases of the 5'-flanking sequence of the human glucocorticoid receptor gene. We identified several transcription start sites, an untranslated exon 1, and the coding content of exon 2.
摘要
糖皮质激素受体信使核糖核酸受糖皮质激素调控。我们在人类糖皮质激素受体基因5'侧翼序列约3千碱基中未发现共有糖皮质激素反应元件、TATA盒或CAAT盒，但发现了许多GC盒。我们确定了几个转录起始位点、一个非翻译的外显子1以及外显子2的编码内容。
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