Odigboegwu Obinnaya, Pan Lu J, Chatterjee Piyali
Department of Internal Medicine, Scott and White Medical Center-Temple, Texas A&M Health Science Center, Temple, TX, United States.
Front Cardiovasc Med. 2018 May 29;5:50. doi: 10.3389/fcvm.2018.00050. eCollection 2018.
Treatment of pregnancy-related hypertensive disorders, such as preeclampsia (PE), remain a challenging problem in obstetrics. Typically, aggressive antihypertensive drug treatment options are avoided to prevent pharmacological-induced hypotension. Another major concern of administering antihypertensive drugs during pregnancy is possible adverse fetal outcome. In addition, management of hypertension during pregnancy in chronic hypertensive patients or in patients with prior kidney problems are carefully considered. Recent studies suggest that PE patients are at increased cardiovascular risk postpartum. Therefore, these patients need to be monitored postpartum for the subsequent development of other cardiovascular diseases. In this review article, we review the antihypertensive drugs currently being used to treat patients with PE and the advantages or disadvantages of using these drugs during pregnancy.
治疗与妊娠相关的高血压疾病，如先兆子痫（PE），仍然是产科中一个具有挑战性的问题。通常，会避免采用积极的抗高血压药物治疗方案，以防止药物引起的低血压。孕期使用抗高血压药物的另一个主要担忧是可能对胎儿产生不良影响。此外，对于慢性高血压患者或既往有肾脏问题的患者，孕期高血压的管理需要仔细考虑。最近的研究表明，PE患者产后心血管风险增加。因此，需要对这些患者产后进行监测，以观察是否会出现其他心血管疾病。在这篇综述文章中，我们回顾了目前用于治疗PE患者的抗高血压药物以及孕期使用这些药物的优缺点。
