子痫前期期间抗高血压药物的使用
Use of Antihypertensive Drugs During Preeclampsia.
作者信息
Odigboegwu Obinnaya, Pan Lu J, Chatterjee Piyali
机构信息
Department of Internal Medicine, Scott and White Medical Center-Temple, Texas A&M Health Science Center, Temple, TX, United States.
出版信息
Front Cardiovasc Med. 2018 May 29;5:50. doi: 10.3389/fcvm.2018.00050. eCollection 2018.
Abstract
Treatment of pregnancy-related hypertensive disorders, such as preeclampsia (PE), remain a challenging problem in obstetrics. Typically, aggressive antihypertensive drug treatment options are avoided to prevent pharmacological-induced hypotension. Another major concern of administering antihypertensive drugs during pregnancy is possible adverse fetal outcome. In addition, management of hypertension during pregnancy in chronic hypertensive patients or in patients with prior kidney problems are carefully considered. Recent studies suggest that PE patients are at increased cardiovascular risk postpartum. Therefore, these patients need to be monitored postpartum for the subsequent development of other cardiovascular diseases. In this review article, we review the antihypertensive drugs currently being used to treat patients with PE and the advantages or disadvantages of using these drugs during pregnancy.
摘要
治疗与妊娠相关的高血压疾病，如先兆子痫（PE），仍然是产科中一个具有挑战性的问题。通常，会避免采用积极的抗高血压药物治疗方案，以防止药物引起的低血压。孕期使用抗高血压药物的另一个主要担忧是可能对胎儿产生不良影响。此外，对于慢性高血压患者或既往有肾脏问题的患者，孕期高血压的管理需要仔细考虑。最近的研究表明，PE患者产后心血管风险增加。因此，需要对这些患者产后进行监测，以观察是否会出现其他心血管疾病。在这篇综述文章中，我们回顾了目前用于治疗PE患者的抗高血压药物以及孕期使用这些药物的优缺点。
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本文引用的文献
1
An analysis of the differences between early and late preeclampsia with severe hypertension.早发型与晚发型重度子痫前期差异分析。
Pregnancy Hypertens. 2016 Jan;6(1):47-52. doi: 10.1016/j.preghy.2015.12.003. Epub 2015 Dec 17.
2
Long-term renal and cardiovascular risk after preeclampsia: towards screening and prevention.子痫前期后的长期肾脏和心血管风险：迈向筛查与预防
Clin Sci (Lond). 2016 Feb;130(4):239-46. doi: 10.1042/CS20150567.
3
Is It Possible to Differentiate Chronic Kidney Disease and Preeclampsia by means of New and Old Biomarkers? A Prospective Study.能否通过新旧生物标志物鉴别慢性肾病和先兆子痫？一项前瞻性研究。
Dis Markers. 2015;2015:127083. doi: 10.1155/2015/127083. Epub 2015 Oct 8.
4
Pre-eclampsia.子痫前期。
Lancet. 2016 Mar 5;387(10022):999-1011. doi: 10.1016/S0140-6736(15)00070-7. Epub 2015 Sep 2.
5
Do labetalol and methyldopa have different effects on pregnancy outcome? Analysis of data from the Control of Hypertension In Pregnancy Study (CHIPS) trial.拉贝洛尔和甲基多巴对妊娠结局的影响是否不同？来自妊娠高血压控制研究（CHIPS）试验的数据分析。
BJOG. 2016 Jun;123(7):1143-51. doi: 10.1111/1471-0528.13569. Epub 2015 Aug 11.
6
Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy.妊娠期高血压。美国妇产科医师学会妊娠期高血压特别工作组报告
Obstet Gynecol. 2013 Nov;122(5):1122-1131. doi: 10.1097/01.AOG.0000437382.03963.88.
7
Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy: a randomized controlled trial.口服硝苯地平或静脉注射拉贝洛尔治疗妊娠高血压急症：一项随机对照试验。
Obstet Gynecol. 2013 Nov;122(5):1057-1063. doi: 10.1097/AOG.0b013e3182a9ea68.
8
Drugs for treatment of very high blood pressure during pregnancy.用于治疗孕期极高血压的药物。
Cochrane Database Syst Rev. 2013 Jul 31;2013(7):CD001449. doi: 10.1002/14651858.CD001449.pub3.
9
Role of antihypertensive therapy in mild to moderate pregnancy-induced hypertension: a prospective randomized study comparing labetalol with alpha methyldopa.抗高血压治疗在轻度至中度妊娠高血压中的作用：一项比较拉贝洛尔和α-甲基多巴的前瞻性随机研究。
Arch Gynecol Obstet. 2012 Jun;285(6):1553-62. doi: 10.1007/s00404-011-2205-2. Epub 2012 Jan 15.
10
Comparison of the efficacy of nifedipine and hydralazine in hypertensive crisis in pregnancy.硝苯地平与肼屈嗪治疗妊娠高血压危象的疗效比较。
Acta Med Iran. 2011;49(11):701-6.
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