Shtivelman E, Lifshitz B, Gale R P, Canaani E
Nature. 1985;315(6020):550-4. doi: 10.1038/315550a0.
Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be produced is probably involved in the malignant process.
人类慢性粒细胞白血病的特征是9号和22号染色体之间发生相互易位，导致22号染色体缩短，并将abl细胞癌基因从9号染色体转移到22号染色体的bcr基因中。对一种慢性粒细胞白血病特有的8千碱基RNA的表征显示，它是这两个基因的融合转录本。可能产生的融合蛋白可能参与了恶性过程。
