Alves Lucas V, Mello Maria J G, Bezerra Patrícia G, Alves João Guilherme Bezerra
1 Department of Paediatrics Neurology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Boa Vista, Recife, Brazil.
J Child Neurol. 2018 Sep;33(10):664-666. doi: 10.1177/0883073818780105. Epub 2018 Jun 13.
Recently described, the congenital Zika syndrome caused by the Zika virus has many features of other congenital infections. This case series study reports 22 infants with congenital Zika syndrome in Brazil who developed infantile spasms during their first year of life. The median age of infantile spasms onset was 4.3 (±1.4) months and ranged from 1 to 7 months. Neurologic evaluation showed that all 22 children presented severe impairment of neuropsychomotor development. A total of 18 infants had an interictal hypsarrhythmia electroencephalogram (EEG) pattern. Vigabatrin was prescribed as first-line treatment; however, only 5 patients were controlled. Steroid regimes were started for children who did not respond to vigabatrin and they are being followed. In conclusion, congenital Zika syndrome may be considered as an etiological agent of infantile spasms.
最近被描述的，由寨卡病毒引起的先天性寨卡综合征具有许多其他先天性感染的特征。本病例系列研究报告了巴西22例患有先天性寨卡综合征的婴儿，他们在出生后的第一年出现了婴儿痉挛症。婴儿痉挛症发作的中位年龄为4.3（±1.4）个月，范围为1至7个月。神经学评估显示，所有22名儿童均出现严重的神经心理运动发育障碍。共有18名婴儿在发作间期脑电图（EEG）表现为高度失律。氨己烯酸被指定为一线治疗药物；然而，只有5名患者得到了控制。对于对氨己烯酸无反应的儿童开始使用类固醇治疗方案，目前正在对他们进行随访。总之，先天性寨卡综合征可能被视为婴儿痉挛症的一种病因。
