MR-based electrical property tomography using a modified finite difference scheme.

Magnetic resonance electrical property tomography (MR-EPT) reconstructs electrical properties (EPs) from measured magnetic fields in magnetic resonance imaging (MRI) systems. In this study, an MR-EPT method was proposed that utilized a new finite difference approximation of the involved differential wave equation. Compared with existing MR-EPT approaches, the construction of the system matrix involves applying the first derivative twice based on a larger number of neighbouring finite-difference grids, which is different from a standard Laplacian operator on a regular grid structure, leading to a better conditioned linear inverse problem. With improved noise robustness, more faithful EPs can be obtained by the proposed method, particularly at tissue boundaries and regions with a poorly measured magnetic field (low signal-to-noise ratio). Numerical simulations with a specially designed multi-slice phantom and an anatomically accurate head model (Duke) have demonstrated that the proposed method can provide a more faithful reconstruction of EPs compared to existing methods, which usually offer unreliable solutions associated with traditional finite difference approximation of the central wave equation and unrealistic assumptions. Experiments on a 9.4 T MRI system have been conducted to validate the simulations.