Department of Chemistry, Indian Institute of Technology Patna, Bihta 801106, Bihar, India.
Chem Commun (Camb). 2018 Jun 26;54(52):7207-7210. doi: 10.1039/c8cc03556c.
An efficient and straightforward method has been developed for the synthesis of polysubstituted phenanthridines from simple aryl iodides and alkyl/aryl nitriles via the palladium-catalyzed nucleophilic addition of aryl iodides to nitriles followed by cascade formation of C-C and C-N bonds viz. in situ generated imine directed sequential two fold C-H activation.
一种高效、直接的方法已经被开发出来，用于通过钯催化的芳基碘化物与腈的亲核加成反应，随后通过 C-C 和 C-N 键的级联形成，从简单的芳基碘化物和烷基/芳基腈合成多取代的菲啶，即原位生成的亚胺导向的顺序双 C-H 活化。
