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1
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.
Cell Metab. 2017 Aug 1;26(2):301-309. doi: 10.1016/j.cmet.2017.07.001.
2
Sensors for the mTORC1 pathway regulated by amino acids.
J Zhejiang Univ Sci B. 2019;20(9):699-712. doi: 10.1631/jzus.B1900181.
3
SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1.
Autophagy. 2016 Jun 2;12(6):1061-2. doi: 10.1080/15548627.2015.1091143. Epub 2015 Oct 2.
4
The amino acid transporter SLC38A9 regulates MTORC1 and autophagy.
Autophagy. 2015;11(10):1709-10. doi: 10.1080/15548627.2015.1084461.
5
Recent advances in understanding of amino acid signaling to mTORC1 activation.
Front Biosci (Landmark Ed). 2019 Mar 1;24(5):971-982. doi: 10.2741/4762.
6
The Central Role of mTORC1 in Amino Acid Sensing.
Cancer Res. 2022 Sep 2;82(17):2964-2974. doi: 10.1158/0008-5472.CAN-21-4403.
8
Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes.
J Biomed Sci. 2020 Aug 17;27(1):87. doi: 10.1186/s12929-020-00679-2.
9
Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling.
Cell Rep. 2016 Aug 9;16(6):1510-1517. doi: 10.1016/j.celrep.2016.07.008. Epub 2016 Jul 28.
10
Amino acid sensing and activation of mechanistic target of rapamycin complex 1: implications for skeletal muscle.
Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):67-73. doi: 10.1097/MCO.0000000000000240.

引用本文的文献

1
Crosstalk between dysregulated amino acid sensing and glucose and lipid metabolism in colorectal cancer.
Front Oncol. 2025 Aug 29;15:1665056. doi: 10.3389/fonc.2025.1665056. eCollection 2025.
2
Differential cell survival outcomes in response to diverse amino acid stress.
Life Sci Alliance. 2025 Sep 5;8(11). doi: 10.26508/lsa.202503324. Print 2025 Nov.
5
mTORC1 senses glutamine and other amino acids through GCN2.
EMBO J. 2025 Jul 21. doi: 10.1038/s44318-025-00505-1.
6
The Molecular Basis of Amino Acids Sensing.
Adv Sci (Weinh). 2025 Jul;12(26):e2501889. doi: 10.1002/advs.202501889. Epub 2025 May 24.
7
Analysis of the mechanism of skeletal muscle atrophy from the pathway of decreased protein synthesis.
Front Physiol. 2025 Apr 25;16:1533394. doi: 10.3389/fphys.2025.1533394. eCollection 2025.
8
Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches.
Cell Rep. 2025 Apr 22;44(4):115529. doi: 10.1016/j.celrep.2025.115529. Epub 2025 Apr 6.
9
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis.
Nat Commun. 2025 Mar 24;16(1):2749. doi: 10.1038/s41467-025-57683-z.
10
Metabolism Meets Translation: Dietary and Metabolic Influences on tRNA Modifications and Codon Biased Translation.
Wiley Interdiscip Rev RNA. 2025 Mar-Apr;16(2):e70011. doi: 10.1002/wrna.70011.

本文引用的文献

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mTOR Signaling in Growth, Metabolism, and Disease.
Cell. 2017 Apr 6;169(2):361-371. doi: 10.1016/j.cell.2017.03.035.
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SZT2 dictates GATOR control of mTORC1 signalling.
Nature. 2017 Mar 16;543(7645):433-437. doi: 10.1038/nature21378. Epub 2017 Feb 15.
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KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Nature. 2017 Mar 16;543(7645):438-442. doi: 10.1038/nature21423. Epub 2017 Feb 15.
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The apo-structure of the leucine sensor Sestrin2 is still elusive.
Sci Signal. 2016 Sep 20;9(446):ra92. doi: 10.1126/scisignal.aah4497.
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Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.
Cell. 2016 Aug 25;166(5):1324-1337.e11. doi: 10.1016/j.cell.2016.07.040.
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Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.
Nature. 2016 Aug 11;536(7615):229-33. doi: 10.1038/nature19079. Epub 2016 Aug 3.
8
Sestrin regulation of TORC1: Is Sestrin a leucine sensor?
Sci Signal. 2016 Jun 7;9(431):re5. doi: 10.1126/scisignal.aaf2885.
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The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.
Cell. 2016 Mar 24;165(1):153-164. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10.

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