聚-L-乳酸（PLLA）的物理化学特性

Physiochemical Characteristics of Poly-L-Lactic Acid (PLLA).

作者信息

Fitzgerald Rebecca, Bass Lawrence M, Goldberg David J, Graivier Miles H, Lorenc Z Paul

机构信息

private practice in Los Angeles, CA.

Department of Plastic Surgery, Manhattan Eye, Ear & Throat Hospital, Zucker School of Medicine at Hofstra/Northwell, New York, NY.

出版信息

Aesthet Surg J. 2018 Apr 6;38(suppl_1):S13-S17. doi: 10.1093/asj/sjy012.

DOI:10.1093/asj/sjy012

PMID:29897517

Abstract

Poly-L-lactic acid (PLLA) is a synthetic, biocompatible, biodegradable polymer. For soft-tissue augmentation, the size and chemical attributes of the PLLA microparticles are central to this agent's ability to promote a subclinical inflammatory response that stimulates deposition of collagen in the extracellular matrix. The resultant restoration of facial volume occurs in a controlled, predictable manner and is long lasting. The unique physiochemical and biostimulatory properties of PLLA differentiate it from other available treatments and are the foundation of the unique treatment methodology required for optimal results.

摘要

聚左旋乳酸（PLLA）是一种合成的、生物相容的、可生物降解的聚合物。对于软组织填充，PLLA微粒的大小和化学属性对于该药物促进亚临床炎症反应的能力至关重要，这种炎症反应会刺激细胞外基质中胶原蛋白的沉积。由此产生的面部容积恢复以可控、可预测的方式发生，且效果持久。PLLA独特的物理化学和生物刺激特性使其有别于其他现有治疗方法，也是获得最佳效果所需独特治疗方法的基础。