使用 1.5T 的 SASHA 序列评估年龄、性别和心力衰竭风险因素对固有心肌 T 值和细胞外容积分数的影响。
Effects of age, gender, and risk-factors for heart failure on native myocardial T and extracellular volume fraction using the SASHA sequence at 1.5T.
机构信息
Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.
Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc, Chicago, Illinois, USA.
出版信息
J Magn Reson Imaging. 2018 Nov;48(5):1307-1317. doi: 10.1002/jmri.26160. Epub 2018 Jun 13.
BACKGROUND
Understanding cardiac MR T mapping values might require examination of the effects of age, gender, and heart failure risk factors.
PURPOSE/HYPOTHESIS: To evaluate the effects of gender, age, and presence of heart failure risk factors on myocardial native T and extracellular volume fraction (ECV).
STUDY TYPE
Retrospective, cross-sectional, observational study.
POPULATION
Secondary analysis of cardiac MR data, separated by gender and health status, based on the presence of at least one heart failure risk factor.
FIELD STRENGTH/SEQUENCE: Cardiac MR imaging at 1.5T, including T mapping using the SAturation recovery single-SHot Acquisition (SASHA) sequence.
ASSESSMENT
Interventricular septal region-of-interest analysis for assessment of native T1 and ECV.
STATISTICAL TESTS
Group comparisons performed using Student t-test, or nonparametric equivalent. Linear regression was used to assess relationships between age and T measurements.
RESULTS
Native T and ECV were available in 187 and 143 subjects, respectively. T and ECV were independent of age in all groups (Native T : healthy women P = 0.655; healthy men P = 0.906; at-risk women P = 0.487; at-risk men P = 0.683; ECV: healthy women P = 0.685; healthy men P = 0.199; at-risk women P = 0.152; at-risk men P = 0.747). T and ECV were higher in healthy women versus men (1202 ± 30 ms versus 1167 ± 36 ms, P = 0.0000 and 22 ± 2% versus 20 ± 2%, P = 0.0089), while values were similar in women and men with risk factors (1197 ± 55 ms versus 1193 ± 45 ms, P = 0.6556, 21 ± 2% versus 21 ± 3%, P = 0.5039). No differences existed in native T or ECV between women with or without risk factors (P = 0.6344 and P = 0.1026), whereas men with risk factors showed higher native T values (P = 0.0070).
DATA CONCLUSION
Native T and ECV measured with SASHA do not vary with age, regardless of gender or the presence of factors for heart failure. Native T and ECV are higher in healthy women than men, but do not differ in the presence of risk factors, suggesting a different myocardial response to risk factors between genders.
LEVEL OF EVIDENCE
3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:1307-1317.
背景
理解心脏磁共振 T 映射值可能需要检查年龄、性别和心力衰竭危险因素的影响。
目的/假设：评估性别、年龄和心力衰竭危险因素对心肌固有 T1 和细胞外容积分数（ECV）的影响。
研究类型
回顾性、横断面、观察性研究。
人群
根据至少存在一个心力衰竭危险因素，对心脏磁共振数据进行性别和健康状况的二次分析。
磁场强度/序列：1.5T 心脏磁共振成像，包括使用饱和恢复单次采集（SASHA）序列进行 T 映射。
评估
评估室间隔感兴趣区分析固有 T1 和 ECV。
统计检验
使用学生 t 检验或非参数等效检验进行组间比较。线性回归用于评估年龄与 T 测量值之间的关系。
结果
分别有 187 名和 143 名受试者的固有 T 和 ECV 可用。在所有组中，T 和 ECV 均与年龄无关（健康女性：T 值 P=0.655；健康男性：T 值 P=0.906；有风险女性：T 值 P=0.487；有风险男性：T 值 P=0.683；ECV 值：健康女性：ECV 值 P=0.685；健康男性：ECV 值 P=0.199；有风险女性：ECV 值 P=0.152；有风险男性：ECV 值 P=0.747）。与男性相比，健康女性的 T 和 ECV 值更高（1202±30 ms 比 1167±36 ms，P=0.0000 和 22±2% 比 20±2%，P=0.0089），而有危险因素的女性和男性之间的 T 和 ECV 值相似（1197±55 ms 比 1193±45 ms，P=0.6556，21±2% 比 21±3%，P=0.5039）。有或没有危险因素的女性之间的固有 T 或 ECV 值没有差异（P=0.6344 和 P=0.1026），而有危险因素的男性显示出更高的固有 T 值（P=0.0070）。
数据结论
使用 SASHA 测量的固有 T 和 ECV 不随年龄变化，无论性别或心力衰竭因素的存在与否。与男性相比，健康女性的固有 T 和 ECV 值更高，但在存在危险因素的情况下，固有 T 和 ECV 值没有差异，这表明性别之间对危险因素的心肌反应不同。
证据水平
3 级。技术功效：3 级。J. Magn. Reson. Imaging 2018；47：1307-1317。
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