Department of Radiology, Center for Clinical Imaging Data Science, Research Institute of Radiological Sciences, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Korea.
Department of Radiology, Research Institute of Radiological Sciences, Yonsei University College of Medicine, 50-1 Yonseiro, Seodaemun-gu, Seoul, Korea.
Eur Radiol. 2022 Dec;32(12):8122-8130. doi: 10.1007/s00330-022-08936-8. Epub 2022 Jun 30.
To investigate the effect of the phantom-based correction method for standardizing myocardial native T1 and extracellular volume fraction (ECV) in healthy subjects.
Seventy-one healthy asymptomatic adult (≥ 20 years) volunteers of five different age groups (34 men and 37 women, 45.5 ± 15.5 years) were prospectively enrolled in three academic hospitals. Cardiac MRI including Modified Look - Locker Inversion recovery T1 mapping sequence was performed using a 3-Tesla system with a different type of scanner for each hospital. Native T1 and ECV were measured in the short-axis T1 map and analyzed for mean values of the 16 entire segments. The myocardial T1 value of each subject was corrected based on the site-specific equation derived from the T1 Mapping and ECV Standardization phantom. The global native T1 and ECV were compared between institutions before and after phantom-based correction, and the variation in native T1 and ECV among institutions was assessed using a coefficient of variation (CoV).
The global native T1 value significantly differed between the institutions (1198.7 ± 32.1 ms, institution A; 1217.7 ± 39.9 ms, institution B; 1232.7 ± 31.1 ms, institution C; p = 0.002), but the mean ECV did not (26.6-27.5%, p = 0.355). After phantom-based correction, the global native T1 and ECV were 1289.7 ± 32.4 ms and 25.0 ± 2.7%, respectively, and CoV for native T1 between the three institutions decreased from 3.0 to 2.5%. The corrected native T1 value did not significantly differ between institutions (1284.5 ± 31.5 ms, institution A; 1296.5 ± 39.1 ms, institution B; 1291.3 ± 29.3 ms, institution C; p = 0.440), and neither did the ECV (24.4-25.9%, p = 0.078).
The phantom-based correction method can provide standardized reference T1 values in healthy subjects.
• After phantom-based correction, the global native T1 of 16 entire myocardial segments on 3-T cardiac MRI is 1289.4 ± 32.4 ms, and the extracellular volume fraction was 25.0 ± 2.7% for healthy subjects. • After phantom - based correction was applied, the differences in the global native T1 among institutions became insignificant, and the CoV also decreased from 3.0 to 2.5%.
研究基于体模的校正方法对健康受试者心肌固有 T1 和细胞外容积分数（ECV）标准化的影响。
前瞻性纳入三所学术医院的 71 名无症状成年志愿者（≥ 20 岁），分为五个不同年龄组（34 名男性和 37 名女性，45.5±15.5 岁）。使用 3.0T 系统进行心脏 MRI 检查，每个医院使用不同类型的扫描仪。使用改良 Look-Locker 反转恢复 T1 映射序列在短轴 T1 图中测量固有 T1 和 ECV，并对 16 个整个节段的平均值进行分析。根据 T1 映射和 ECV 标准化体模得出的特定部位方程，对每个受试者的心肌 T1 值进行校正。在基于体模校正前后比较机构间的整体固有 T1 和 ECV，并使用变异系数（CoV）评估机构间固有 T1 和 ECV 的变化。
机构间整体固有 T1 值差异有统计学意义（1198.7±32.1 ms，机构 A；1217.7±39.9 ms，机构 B；1232.7±31.1 ms，机构 C；p=0.002），但平均 ECV 无差异（26.6-27.5%，p=0.355）。基于体模校正后，整体固有 T1 和 ECV 分别为 1289.7±32.4 ms 和 25.0±2.7%，三个机构间固有 T1 的 CoV 从 3.0 降至 2.5%。校正后的固有 T1 值在机构间无显著差异（1284.5±31.5 ms，机构 A；1296.5±39.1 ms，机构 B；1291.3±29.3 ms，机构 C；p=0.440），ECV 也无差异（24.4-25.9%，p=0.078）。
基于体模的校正方法可为健康受试者提供标准化的参考 T1 值。
在 3T 心脏 MRI 上，16 个整个心肌节段的整体校正后心肌固有 T1 为 1289.4±32.4 ms，健康受试者的细胞外容积分数为 25.0±2.7%。
基于体模校正后，机构间整体固有 T1 的差异变得无统计学意义，CoV 也从 3.0 降至 2.5%。
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