经皮电刺激神经疗法（TENS）对头颈部放疗引起的唾液分泌减少的影响：一项初步研究。

Transcutaneous Electrical Nerve Stimulation (TENS) on hyposalivation induced by radiotherapy in the head and neck region: a preliminary study.

作者信息

Paim Émille Dalbem, Macagnan Fabricio Edler, Martins Vera Beatris, Zanella Virgilio Gonzales, Guimarães Bruno, Berbert Monalise Costa Batista

机构信息

Irmandade Santa Casa de Misericórdia de Porto Alegre - ISCMPA - Porto Alegre (RS), Brasil.

Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA - Porto Alegre (RS), Brasil.

出版信息

Codas. 2018 Jun 7;30(3):e20170143. doi: 10.1590/2317-1782/20182017143.

DOI:10.1590/2317-1782/20182017143

PMID:29898038

Abstract

PURPOSE

To verify the acute effect of electrostimulation on the salivary flow of patients with hyposalivation.

METHODS

Uncontrolled clinical trial evaluating 15 patients with hyposalivation induced by radiotherapy (RT) used for head and neck cancer treatment. Mean age of the patients was 56.8 ± 6.46 years. Males outnumbered females (73%). Transcutaneous Electrical Nerve Stimulation (TENS) was adjusted with 50Hz of frequency and 250μs of pulse width. Intensity was adjusted over a 20-minute period according to maximum tolerance. The electrodes were attached bilaterally on the region of the salivary glands. Evaluation of the salivary flow was performed through sialometry before and immediately after application of TENS.

RESULTS

The most prevalent region for RT was the oropharynx (80.0% of cases). The mean dose used in RT was 64.6 ± 7.27 Gy. After TENS, salivary flow increased significantly (p = 0.0051) from 0.05 (0.00; 0.40) mL/min to 0.10 (0.07: 0.40) mL/min. The response to TENS was directly correlated with the intensity of the tolerated electric current (r = 0.553; p = 0.032) and the dose used in RT (r = -0.514; p = 0.050).

CONCLUSION

TENS was able to increase the salivary flow rate of patients with RT-induced hyposalivation.

摘要

目的

验证电刺激对唾液分泌减少患者唾液流量的急性影响。

方法

一项非对照临床试验，评估15例因头颈部癌放疗（RT）导致唾液分泌减少的患者。患者平均年龄为56.8±6.46岁。男性多于女性（73%）。经皮神经电刺激（TENS）的频率调整为50Hz，脉冲宽度调整为250μs。在20分钟内根据最大耐受程度调整强度。电极双侧贴于唾液腺区域。在应用TENS之前和之后立即通过唾液流量测定法评估唾液流量。

结果

放疗最常见的区域是口咽（80.0%的病例）。放疗中使用的平均剂量为64.6±7.27Gy。TENS治疗后，唾液流量从0.05（0.00；0.40）mL/分钟显著增加（p = 0.0051）至0.10（0.07：0.40）mL/分钟。对TENS的反应与耐受电流强度直接相关（r = 0.553；p = 0.032），与放疗中使用的剂量也直接相关（r = -0.514；p = 0.050）。