电刺激对2型糖尿病患者全唾液流量的有效性
Effectiveness of Electrostimulation on Whole Salivary Flow Among Patients with Type 2 Diabetes Mellitus.
作者信息
Dyasnoor Sujatha, Kamath Shwetha, Khader Nishat Fatima Abdul
机构信息
Professor of Oral Medicine and Maxillofacial Radiology at The Oxford Dental College and Research Hospital in Bangalore, Karnataka, India.
Clinical Practitioner in the Department of Oral Medicine and Radiology at The Oxford Dental College and Research Hospital in Bangalore, Karnataka, India.
出版信息
Perm J. 2017;21:15-164. doi: 10.7812/TPP/15-164.
CONTEXT
Xerostomia and hyposalivation are associated with diabetes. Research is sparse regarding electrostimulation as a mainstream therapy for salivary gland hypofunction.
OBJECTIVE
To clinically evaluate the effectiveness of transcutaneous electric nerve stimulation (TENS) therapy in stimulating whole salivary flow among patients with xerostomia and hyposalivation caused by diabetes mellitus.
DESIGN
Forty patients between age 30 to 75 years with diabetes mellitus categorized as controlled or uncontrolled who had subjective symptoms of xerostomia and an objective sign of hyposalivation were included in a prospective study.
MAIN OUTCOME MEASURES
Unstimulated saliva through the "low forced spitting" method and stimulated saliva collection using TENS were assessed and compared. Longer-term effects of TENS application were evaluated by recalling the patient 24 hours later.
RESULTS
A statistically significant increase in stimulated whole saliva after TENS application in continuous mode (p < 0.001) was demonstrated compared with unstimulated saliva, especially in xerostomic patients with diabetes. Burst mode inferred a statistically significant decrease in salivary flow (p < 0.001).
CONCLUSION
In patients with diabetes with xerostomia and hyposalivation, TENS was highly effective in stimulating whole salivary flow.
背景
口干症和唾液分泌减少与糖尿病有关。关于电刺激作为唾液腺功能减退的主流治疗方法的研究较少。
目的
临床评估经皮电神经刺激（TENS）疗法对糖尿病引起的口干症和唾液分泌减少患者刺激全唾液分泌的有效性。
设计
一项前瞻性研究纳入了40名年龄在30至75岁之间的糖尿病患者，这些患者分为血糖控制良好或控制不佳组，均有口干的主观症状和唾液分泌减少的客观体征。
主要观察指标
通过“低强制吐唾”方法评估未刺激唾液，并使用TENS评估和比较刺激唾液的收集情况。在24小时后回访患者，评估TENS应用的长期效果。
结果
与未刺激唾液相比，连续模式下应用TENS后刺激全唾液有统计学显著增加（p < 0.001），尤其是糖尿病口干患者。突发模式下唾液流量有统计学显著减少（p < 0.001）。
结论
对于患有糖尿病且有口干症和唾液分泌减少的患者，TENS在刺激全唾液分泌方面非常有效。
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