Emmons R W
Prog Clin Biol Res. 1985;178:47-52.
Certain features of Colorado tick fever (CTF) virus and the disease it causes may be relevant to studies on bluetongue virus (BTV), or other orbiviruses. Rapid and easy detection of viral antigen in infected tissues and peripheral blood cells by immunofluorescence staining facilitate diagnosis of the disease. The prolonged (3-4 months) viremia is due to persistent intracellular infection, particularly of erythrocytes, in which the virus is protected from antibody or other host defense mechanisms. This results in more efficient maintenance of the virus cycle in nature, but might lead to adverse effects in the human host. Clues to understanding chronic viral infections or viral immunosuppression might be gained by further research on CTF and other orbiviruses.
科罗拉多蜱传热（CTF）病毒及其所引发疾病的某些特征可能与蓝舌病毒（BTV）或其他环状病毒的研究相关。通过免疫荧光染色在感染组织和外周血细胞中快速简便地检测病毒抗原有助于疾病的诊断。病毒血症持续时间较长（3 - 4个月）是由于细胞内持续感染，特别是红细胞感染，病毒在其中受到抗体或其他宿主防御机制的保护。这使得病毒在自然界中更有效地维持循环，但可能会对人类宿主产生不良影响。通过对CTF和其他环状病毒的进一步研究，可能会获得有关理解慢性病毒感染或病毒免疫抑制的线索。
