恶性胸膜间皮瘤的比较蛋白质组学分析：聚焦双相亚型。
Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype.
作者信息
Giusti Laura, Ciregia Federica, Bonotti Alessandra, Da Valle Ylenia, Donadio Elena, Boldrini Claudia, Foddis Rudy, Giannaccini Gino, Mazzoni Maria R, Canessa Pier Aldo, Cristaudo Alfonso, Lucacchini Antonio
机构信息
Department of Pharmacy, University of Pisa, Pisa, Italy.
Preventive and Occupational Medicine, University Hospital of Pisa, Pisa, Italy.
出版信息
EuPA Open Proteom. 2016 Jan 16;10:42-49. doi: 10.1016/j.euprot.2016.01.006. eCollection 2016 Mar.
Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes.
恶性胸膜间皮瘤（MPM）是一种起源于胸膜间皮细胞的罕见癌症。MPM与长期接触石棉有关。在这项工作中，我们对双相性胸膜间皮瘤（B-PM）进行了比较蛋白质组学分析。从61例行诊断性胸腔镜检查的患者中获取组织活检样本。基于二维质谱的方法用于蛋白质组学分析。通过Ingenuity Pathways Analysis对在B-PM中相对于良性病变发现差异表达的22种蛋白质进行分析，并与上皮样胸膜间皮瘤（E-PM）所获得的蛋白质进行比较。在两种亚型之间观察到转录因子、蛋白质和细胞因子的不同激活情况。
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