Khatib Sohaib, Asad Osama, Asad Hussein, Sabobeh Taher
Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, USA.
Internal Medicine, Jordan University of Science and Technology, Irbid, JOR.
Cureus. 2021 Aug 15;13(8):e17199. doi: 10.7759/cureus.17199. eCollection 2021 Aug.
Malignant pleural mesothelioma (MPM) is a highly aggressive malignant tumor that arises from mesothelial cells of pleural cavity. The main risk factor for MPM is asbestos exposure with most cases discovered in elderly males after a long latency period. However, here we report a rare case of MPM diagnosed in a healthy young male patient without significant asbestos exposure. We report the case of an otherwise healthy 47-year-old male who presented with one week of exertional dyspnea and chest pain. Chest X-ray showed unilateral large pleural effusion. Chest CT scan revealed confluent right hilar mass and pleural thickening. Pleural fluid analysis showed exudative features. Cytology was negative for malignant cells. Core tissue biopsy showed features of epithelioid mesothelioma. Although most cases of MPM have been reported in elderly male patients with significant asbestos exposure, more research is needed to explain the pathogenesis of MPM in young patients without asbestos exposure.
恶性胸膜间皮瘤（MPM）是一种具有高度侵袭性的恶性肿瘤，起源于胸膜腔的间皮细胞。MPM的主要危险因素是接触石棉，大多数病例在长期潜伏期后于老年男性中发现。然而，在此我们报告一例罕见的MPM病例，该病例发生在一名无明显石棉接触史的健康年轻男性患者身上。我们报告了一例原本健康的47岁男性病例，该患者出现了一周的劳力性呼吸困难和胸痛。胸部X线显示单侧大量胸腔积液。胸部CT扫描显示右肺门肿块融合及胸膜增厚。胸腔积液分析显示为渗出性特征。细胞学检查未发现恶性细胞。核心组织活检显示为上皮样间皮瘤特征。尽管大多数MPM病例报告发生在有明显石棉接触史的老年男性患者中，但仍需要更多研究来解释无石棉接触史的年轻患者中MPM的发病机制。
