van der Kraan Peter M
Department of Rheumatology, Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands.
J Bone Metab. 2018 May;25(2):65-72. doi: 10.11005/jbm.2018.25.2.65. Epub 2018 May 31.
Transforming growth factor-β (TGF-β) is a cytokine that plays an important role in both normal joints and joints affected by osteoarthritis (OA), the most common joint disease. However, the role of this pleiotropic cytokine in a normal healthy joint is very different from its role in an OA joint. In a normal synovial joint, active TGF-β is only present after joint loading and only for a short period. In contrast, permanent and high levels of active TGF-β are detected in OA joints. Due to this difference in levels and exposure period of joint cells to active TGF-β, the function of TGF-β is strikingly different in normal and OA joints. The consequences of this difference in TGF-β levels on joint homeostasis and pathological changes in OA joints are discussed in this review.
转化生长因子-β（TGF-β）是一种细胞因子，在正常关节和受骨关节炎（OA，最常见的关节疾病）影响的关节中均发挥重要作用。然而，这种多效性细胞因子在正常健康关节中的作用与其在OA关节中的作用截然不同。在正常滑膜关节中，活性TGF-β仅在关节负荷后出现且仅持续短时间。相比之下，在OA关节中可检测到持续且高水平的活性TGF-β。由于关节细胞接触活性TGF-β的水平和暴露时间存在这种差异，TGF-β在正常关节和OA关节中的功能显著不同。本综述讨论了TGF-β水平差异对关节稳态和OA关节病理变化的影响。
